PMID: 9540818Apr 16, 1998Paper

Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells

Biochimica Et Biophysica Acta
C Giardina, M S Inan

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) and short-chain fatty acids are effective suppressors of colorectal cancer that may work in part by accentuating apoptosis of transformed cells. Since reactive oxygen species (ROS) can play an important role in regulating cell growth and cell death, we determined the effect of the NSAIDs indomethacin and salicylic acid, and the short-chain fatty acids butyrate and propionate on ROS metabolism in the HT-29 human colorectal carcinoma cell line. We find that all of these agents increase cellular peroxide generation, as determined by two independent assays. Arachidonic acid was also found to increase ROS generation, and could synergize with indomethacin in this reaction. The NSAIDs and short-chain fatty acids under study all possess a carboxyl group, and this carboxyl group is essential for salicylic acid's ability to increase ROS production. Although the two NSAIDs examined increase peroxide production, they were both found to suppress superoxide generation by vitamin K3 (menadione), a redox cycling compound similar to those found in the colon. The short-chain fatty acids did not have this activity. The ability of these NSAIDs and short-chain fatty acids to alter cellular ROS metabolis...Continue Reading

References

Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·L GametJ C Murat
Jan 1, 1989·Free Radical Research Communications·M H BlakeboroughR F Bilton
Dec 22, 1995·Science·B Frantz, E A O'Neill
Mar 14, 1997·Science·K IraniP J Goldschmidt-Clermont

❮ Previous
Next ❯

Citations

Feb 3, 2000·Free Radical Biology & Medicine·B ChénaisP Jeannesson
Aug 29, 2013·Oxidative Medicine and Cellular Longevity·Gianluca Farrugia, Rena Balzan
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·S PonistK Bauerova
Mar 19, 2013·Carbohydrate Polymers·Amélia C F VieiraAntónio M d'A Rocha Gonsalves
Jul 29, 2008·Archives of Biochemistry and Biophysics·S Prasanna KumarB P Salimath
Aug 18, 2005·Biochemical and Biophysical Research Communications·Madesh BelakavadiBharathi P Salimath
Mar 11, 2004·Differentiation; Research in Biological Diversity·Martina KovaríkováAlois Kozubík
Oct 13, 2015·Oxidative Medicine and Cellular Longevity·Rajeshwary GhoshAldrin V Gomes
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Sandra TanShing Chuan Hooi
Jan 2, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jacob J BriedéJos C S Kleinjans
Dec 19, 2016·The International Journal of Biochemistry & Cell Biology·Aleksandar PantovicLjubica Harhaji-Trajkovic
Apr 25, 2007·The Journal of Biological Chemistry·Jianli WangYuxin Yin
Jul 28, 2009·Free Radical Research·Lucia RackovaTilman Grune
Sep 24, 2013·Metallomics : Integrated Biometal Science·Ilaria ZanellatoDomenico Osella
Sep 27, 2001·The Journal of Biological Chemistry·L YinC Giardina
Jul 6, 2017·BioMed Research International·Thais Herrero GeraldinoGabriela Pereira-da-Silva
Oct 6, 2000·Molecular Carcinogenesis·M S InanC Giardina
Feb 8, 2002·World Journal of Gastroenterology : WJG·Jian-Wei ZhuDong-Hua Li
Oct 31, 2019·World Journal of Gastrointestinal Oncology·Kendra J RoystonOlufunmilayo I Olopade
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian SinaPhilip Rosenstiel
Apr 12, 2008·Molecular Cancer Research : MCR·Yu-Xin LiuYuxin Yin
Nov 26, 2019·Journal of Pediatric Gastroenterology and Nutrition·Ahmed M El-LekawyHanan S El-Abhar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.