Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production

Cytokine
I TsuboiK Itoh

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known as immunoregulators, but the mechanisms of their action are not fully explained by the inhibition of PG synthesis. We have investigated the effect of NSAIDs on cytokine production in human PBMC and T cell clones (TCC). NSAIDs up-regulated TNF, IFN-gamma and IL-2 production at both the mRNA and protein levels, and IL-12 expression at the mRNA level. In contrast, NSAIDs down-regulated IL-6 production both at the mRNA and protein levels, and down-regulated IL-4 mRNA expression. The modulation at the mRNA level became detectable 1 h after culture. This modulation was also observed at the level of TCC. Indomethacin (IM) enhanced TNF production in all the eight TCC that were established from a patient with human T lymphotrophic virus type 1 uveitis or pulmonary sarcoidosis, and suppressed IL-6 production in six of the eight TCC, without affecting their low levels of PGE2 production. IM also enhanced TNF and suppressed IL-6 production, respectively, in both IL-2-activated PBMC and IL-2-dependent NK cell line, with the inhibition of their high levels of PGE2 production. Culture with PGE2 alone suppressed TNF production by three of the six TCC and NK cell lines, which was neut...Continue Reading

Citations

Apr 29, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K MazumdarN K Dutta
Oct 1, 2013·Pharmacology & Therapeutics·Xin YaoYihong Yao
Nov 11, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A E VarnerR F Lemanske
Jun 20, 2001·Biological & Pharmaceutical Bulletin·B S KangY Kim
Feb 11, 2005·Journal of the American Veterinary Medical Association·Jean-Jacques Kona-BounEric Troncy
Dec 17, 2009·World Journal of Gastroenterology : WJG·Annagiulia GramenziPietro Andreone
Jun 12, 2010·European Journal of Anaesthesiology·Evelyne CombettesHélène Beloeil
Nov 20, 2009·The International Journal of Neuroscience·Joseph Prandota
Oct 17, 2015·International Journal of Molecular Sciences·Barbara Stypińska, Agnieszka Paradowska-Gorycka
May 18, 2010·Current Medical Research and Opinion·Tong J Gan
May 21, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Shinnosuke NogamiKensuke Yamauchi
Oct 31, 2012·Cytokine & Growth Factor Reviews·Parvin Ataie-KachoieDavid L Morris
Dec 23, 2008·Toxicology Letters·Kiyoshi KushimaMichio Fujiwara
Jan 25, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H MoedT Rustemeyer
Nov 22, 2007·The British Journal of Dermatology·M J ToebakT Rustemeyer
Dec 17, 2008·International Journal of Cancer. Journal International Du Cancer·Andrzej SlominskiRadomir Slominski
Jul 23, 2008·Letters in Applied Microbiology·N K DuttaJ H Park
Feb 24, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Akihisa OkumuraTsuneo Morishima
May 20, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·N A SandlerT W Braun
Mar 20, 2010·FEMS Immunology and Medical Microbiology·Eleuza R MachadoLúcia H Faccioli
Sep 1, 2016·Biochemical and Biophysical Research Communications·Bo-Young KimKoanhoi Kim
Aug 5, 2017·Biomarkers in Medicine·Jinrong ZengQianjin Lu
Aug 3, 2019·Veterinary Medicine and Science·Sandra M Axiak-BechtelAmy E DeClue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.