Nonsteroidal Antiinflammatory Drugs for Axial Spondyloarthritis: A Cochrane Review

The Journal of Rheumatology
Féline Pb KroonDésirée van der Heijde

Abstract

To determine the benefits and harms of nonsteroidal antiinflammatory drugs (NSAID) in axial spondyloarthritis (axSpA). Systematic review using Cochrane Collaboration methodology. randomized controlled trials (RCT) and quasi-RCT (to June 2014), investigating NSAID versus any control for axSpA, and observational studies of longterm effects (≥ 6 mos) of NSAID on radiographic progression or adverse events. Main outcomes were pain, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index, radiographic progression, number of withdrawals because of adverse events, and number of serious adverse events. Risk of bias was assessed. Thirty-five RCT, 2 quasi-RCT, and 2 cohort studies were included. Twenty-nine RCT and 2 quasi-RCT (n = 4356) were included in pooled analyses [traditional NSAID vs placebo (n = 5), cyclooxygenase-2 (COX-2) vs placebo (n = 3), COX-2 vs traditional NSAID (n = 4), NSAID vs NSAID (n = 24), naproxen vs other NSAID (n = 3), and low- vs high-dose NSAID (n = 5)]. Compared with placebo, both traditional and COX-2 NSAID were consistently more efficacious at 6 weeks and equally safe after 12 weeks. No significant differences in benefits o...Continue Reading

References

Jan 1, 1977·Current Medical Research and Opinion·A Good, H Mena
Apr 20, 1977·European Journal of Clinical Pharmacology·H R Mena, R F Willkens
Aug 1, 1977·Southern Medical Journal·H R Mena, A E Good
Oct 1, 1978·Annals of the Rheumatic Diseases·B M AnsellC Engler
May 15, 1978·Harefuah·A M NahirL Koren
Jan 1, 1976·Rheumatology and Rehabilitation·J D Jessop
Jan 1, 1990·Current Medical Research and Opinion·A C SchwarzerP M Brooks
Oct 1, 1990·Seminars in Arthritis and Rheumatism·M A Khan, S M van der Linden
Sep 1, 1988·Annals of Internal Medicine·M R GriffinW Schaffner
Mar 1, 1988·The Journal of International Medical Research·J E Santo, M V Queiroz
Apr 28, 1986·The American Journal of Medicine·J J Calabro
Jun 1, 1986·Clinical Rheumatology·M J FranssenL B van de Putte
Jan 1, 1966·Annals of Physical Medicine·M R SimpsonD C Beatty
Feb 1, 1984·British Journal of Rheumatology·K LehtinenA Gordin
Aug 1, 1980·Rheumatology and Rehabilitation·A M Nahir, Y Scharf
Oct 1, 1993·Journal of Clinical Gastroenterology·R Stalnikowicz, D Rachmilewitz
Jan 1, 1994·Scandinavian Journal of Rheumatology·M DougadosC Gomeni
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·M D Murray, D C Brater
Dec 2, 1999·JAMA : the Journal of the American Medical Association·L S SimonG S Geis
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Feb 17, 2005·The New England Journal of Medicine·Robert S BresalierUNKNOWN Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators
Mar 22, 2006·Annals of Internal Medicine·Jill A HaydenClaire Bombardier

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Citations

Jun 22, 2006·Journal of Science and Medicine in Sport·Judith J MayWill G Hopkins
May 20, 2017·Digestive Diseases and Sciences·Vikesh K Singh, Asbjørn M Drewes
Feb 25, 2018·Expert Opinion on Emerging Drugs·Judith Rademacher, Denis Poddubnyy
Dec 24, 2017·Arthritis Research & Therapy·Nilasha Ghosh, Eric M Ruderman
Feb 23, 2019·Rheumatology and Therapy·Philip C RobinsonStefan Siebert
Sep 19, 2019·Zeitschrift für Rheumatologie·U Kiltz, J Braun
Sep 24, 2020·Therapeutic Advances in Musculoskeletal Disease·Judith RademacherUwe Pleyer
Oct 15, 2020·Rheumatology·George E Fragoulis, Stefan Siebert
Oct 8, 2021·Annals of the Rheumatic Diseases·Victoria Navarro-CompánDésirée van der Heijde

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