Nonsteroidal antiinflammatory drugs, cyclooxygenase polymorphisms, and the risk of developing breast carcinoma among women with benign breast disease

Cancer
Lisa GallicchioKathy J Helzlsouer

Abstract

Biopsy-proven benign breast disease (BBD) is a risk factor for developing breast carcinoma; however, to the authors' knowledge, little is known regarding factors related to progression to carcinoma. A cohort study was conducted to examine the role of cyclooxygenase (COX) polymorphisms and nonsteroidal anti-inflammatory drugs (NSAIDs) in the progression of BBD to breast carcinoma. Among participants in an ongoing cohort study, 1467 women underwent a breast biopsy for BBD. Of these women, 91 subsequently developed breast carcinoma. Medication data were collected in 1989 and in 1996. COX genotypes were determined using DNA extracted from blood specimens collected in 1989. A decrease in breast carcinoma risk was observed among women who reported using aspirin in 1989 (odds ratio [OR] of .46; 95% confidence interval [95% CI], .22-.98) and in 1996 (OR of .47, 95% CI, .18-1.21). Furthermore, a higher frequency, dose, and longer duration of aspirin use were associated with a decrease in the odds of developing breast carcinoma. Overall, no association was observed between COX genotypes and the subsequent development of breast carcinoma. However, among women not using NSAIDs, one COX-2 polymorphism (rs2143416) was found to be significant...Continue Reading

References

Sep 1, 1988·American Journal of Epidemiology·C L CarterP R Taylor
Mar 1, 1995·Preventive Medicine·R E HarrisE L Wynder
Mar 1, 1994·Epidemiology·D M Schreinemachers, R B Everson
Sep 1, 1996·The Journal of Laboratory and Clinical Medicine·K K Wu
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
Apr 1, 1998·Journal of the National Cancer Institute·D HwangE Levine
Jun 9, 2001·Endocrine-related Cancer·L R HoweA J Dannenberg
Jan 13, 2004·Menopause : the Journal of the North American Menopause Society·László B Tankó, Claus Christiansen
May 27, 2004·JAMA : the Journal of the American Medical Association·Mary Beth TerryAlfred I Neugut
Jun 3, 2004·British Journal of Cancer·D G CoxUNKNOWN Bellvitge Colorectal Cancer Study Group
Jul 1, 2004·British Journal of Cancer·L A García Rodríguez, A González-Pérez
Jul 22, 2005·The New England Journal of Medicine·Lynn C HartmannDaniel W Visscher

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Citations

Mar 17, 2006·Breast Cancer Research and Treatment·Lisa GallicchioKathy J Helzlsouer
Nov 4, 2008·Breast Cancer Research and Treatment·Ya-shuang ZhaoXia Li
Nov 12, 2010·Breast Cancer Research and Treatment·Katherine W ReevesBrenda Diergaarde
Nov 1, 2011·Breast Cancer Research and Treatment·Juliana S Festa-VasconcellosRosane Vianna-Jorge
May 27, 2009·Cancer Causes & Control : CCC·Daniel IglesiasAntonia M Fernández-Peralta
Sep 13, 2007·Cancer Metastasis Reviews·Yong Q ChenIsabelle M Berquin
Apr 1, 2010·Medical Oncology·Nagehan Ozdemir BarısıkNimet Karadayı
Jul 3, 2010·Journal of Gastroenterology and Hepatology·Jing DongHongbing Shen
May 17, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A YoshidaS F M Derchain
Apr 4, 2014·Cancer Metastasis Reviews·David G MenterKenneth V Honn
Dec 19, 2015·Mayo Clinic Proceedings·Aditya BardiaJames R Cerhan
Mar 17, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Javier de la TorreJordi Xercavins
Jan 16, 2015·Breast Cancer Research and Treatment·María de PedroJavier Llorca
Oct 30, 2016·Molecular Nutrition & Food Research·Nitin ShivappaCarlo La Vecchia
Oct 11, 2014·World Journal of Clinical Oncology·Randall E HarrisZachary M Harris
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xi YangCheng Yi
Feb 6, 2017·Breast Cancer Research and Treatment·Marie E WoodDespina Kontos
Nov 13, 2020·The Journal of Clinical Endocrinology and Metabolism·Sofija Mijic, Charlotta Dabrosin
Jul 29, 2020·Cancer Prevention Research·Mark E ShermanAmy C Degnim
May 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary Beth TerryYuyan Liao
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David G MenterRaymond N DuBois
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kirsten B MoysichJulie A Baker
Jul 13, 2021·Frontiers in Oncology·Jennifer M MongioviZhihong Gong
Oct 12, 2021·Nucleosides, Nucleotides & Nucleic Acids·Tahereh ZahediJahan-Bakhsh Raoof

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