Nonstructural proteins NS7b and NS8 are likely to be phylogenetically associated with evolution of 2019-nCoV

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Muhamad FahmiMasahiro Ito

Abstract

The seventh novel human infecting Betacoronavirus that causes pneumonia (2019 novel coronavirus, 2019-nCoV) originated in Wuhan, China. The evolutionary relationship between 2019-nCoV and the other human respiratory illness-causing coronavirus is not closely related. We sought to characterize the relationship of the translated proteins of 2019-nCoV with other species of Orthocoronavirinae. A phylogenetic tree was constructed from the genome sequences. A cluster tree was developed from the profiles retrieved from the presence and absence of homologs of ten 2019-nCoV proteins. The combined data were used to characterize the relationship of the translated proteins of 2019-nCoV to other species of Orthocoronavirinae. Our analysis reliably suggests that 2019-nCoV is most closely related to BatCoV RaTG13 and belongs to subgenus Sarbecovirus of Betacoronavirus, together with SARS coronavirus and Bat-SARS-like coronavirus. The phylogenetic profiling cluster of homolog proteins of one annotated 2019-nCoV protein against other genome sequences revealed two clades of ten 2019-nCoV proteins. Clade 1 consisted of a group of conserved proteins in Orthocoronavirinae comprising Orf1ab polyprotein, Nucleocapsid protein, Spike glycoprotein, and ...Continue Reading

Citations

Jun 25, 2020·The Journal of General Virology·Severino Jefferson Ribeiro da SilvaLindomar Pena
Jun 18, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Martin Alexander LauxmannAna María Autrán-Gómez
Aug 10, 2020·Microscopy Research and Technique·Sindhoora Kaniyala MelanthotaNirmal Mazumder
Aug 25, 2020·Indian Journal of Clinical Biochemistry : IJCB·Subir Kumar Das
Aug 25, 2020·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·P Chellapandi, S Saranya
Dec 12, 2020·The Journal of Gene Medicine·Malihe MohamadianAbdolreza Esmaeilzadeh
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ziyad Tariq MuhseenGuanglin Li
Dec 2, 2020·Medical Hypotheses·Eduardo Pérez-Campos MayoralEduardo Pérez-Campos
Apr 5, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Irene CassanitiFausto Baldanti
Sep 24, 2020·Current Topics in Medicinal Chemistry·Satya P Gupta
Apr 30, 2021·Frontiers in Immunology·Jintao ZhangWei Zhao
Jun 13, 2021·Journal of Infection and Public Health·Vartika Srivastava, Aijaz Ahmad
Jun 16, 2021·Journal of Infection and Public Health·Ahmed S KeshtaPatrick Tang
Aug 14, 2020·ACS Infectious Diseases·Severino Jefferson Ribeiro da SilvaLindomar Pena

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Methods Mentioned

BETA
phylogenetic profiling

Software Mentioned

NG
BLAST
RAxML
MAFFT
FigTree
I TASSER
DICHOT
ModelTest
MEGA X
TASSER

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