Nonsurgical weight loss for extreme obesity in primary care settings: results of the Louisiana Obese Subjects Study

Archives of Internal Medicine
Donna H RyanLars Sjöström

Abstract

Effective primary care practice (PCP) treatments are needed for extreme obesity. The Louisiana Obese Subjects Study (LOSS) tested whether, with brief training, PCPs could effectively implement weight loss for individuals with a body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) of 40 to 60. The LOSS, a 2-year (July 5, 2005, through January 30, 2008) randomized, controlled, "pragmatic clinical trial" trained 7 PCPs and 1 research clinic in obesity management. Primary outcome measure was year-2 percentage change from baseline weight. Volunteers (597) were screened and randomized to intensive medical intervention (IMI) (n = 200) or usual care condition (UCC) (n = 190). The UCC group had instruction in an Internet weight management program. The IMI group recommendations included a 900-kcal liquid diet for 12 weeks or less, group behavioral counseling, structured diet, and choice of pharmacotherapy (sibutramine hydrochloride, orlistat, or diethylpropion hydrochloride) during months 3 to 7 and continued use of medications and maintenance strategies for months 8 to 24. The mean age of participants was 47 years; 83% were women, and 75% were white. Retention rates were 51% for the IMI group and...Continue Reading

Associated Clinical Trials

Jun 21, 2005·Donna H. Ryan, MD, Donna H. Ryan, MD

Citations

Feb 8, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·A MartinM Badell
Jul 1, 2014·American Journal of Health Promotion : AJHP·Valerie H MyersDonna H Ryan
Jul 27, 2014·The Journal of Endocrinology·Michael Rosenbaum, Rudolph L Leibel
Oct 12, 2010·JAMA : the Journal of the American Medical Association·Bret H GoodpasterJohn M Jakicic
May 24, 2011·The Journal of Clinical Endocrinology and Metabolism·Robert H EckelSteven R Smith
Jun 16, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S C BischoffT Ellrott
Jan 5, 2013·American Journal of Health Promotion : AJHP·Holly C Felix, Delia S West
Mar 1, 2012·The Journal of Behavioral Health Services & Research·Claire E AdamsPatricia M Dubbert
Dec 15, 2015·Clinical Endocrinology·Julian H Barth, Mary O'Kane
Jul 23, 2011·Obesity·Thomas A WaddenUNKNOWN Look AHEAD Research Group
Feb 4, 2016·Clinical Endocrinology·Prapimporn Chattranukulchai ShantavasinkulLeonor Corsino
May 2, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Samyah ShadidMichael D Jensen
May 24, 2011·Diabetes Care·Robert H EckelUNKNOWN European Association for the Study of Diabetes
Feb 16, 2013·The American Journal of Medicine·Jessica L UnickUNKNOWN Look AHEAD Research Group
Nov 16, 2011·The New England Journal of Medicine·Thomas A WaddenReneé H Moore
Dec 27, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A CourcoulasC Gostout
Aug 17, 2012·The Cochrane Database of Systematic Reviews·L Susan WielandKarina W Davidson
Oct 10, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N V Dhurandhar
Jun 28, 2018·International Journal of Qualitative Studies on Health and Well-being·Eli NatvikChristian Moltu
Nov 15, 2018·Hispanic Health Care International : the Official Journal of the National Association of Hispanic Nurses·Francia G PortacioMark Stoutenberg
May 1, 2013·Expert Review of Endocrinology & Metabolism·Sunil J Wimalawansa
Oct 13, 2017·Eating and Weight Disorders : EWD·Rebecca L VenchiaruttiCaron S Blumenthal
Feb 18, 2018·BMJ Open·Elizabeth A SturgissKirsty A Douglas
Oct 20, 2017·Obesity Surgery·Sergio SusmallianAsnat Raziel
May 3, 2020·International Journal of Environmental Research and Public Health·Phillip J BrantleyGang Hu
Jul 14, 2010·Southern Medical Journal·James V Lewis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.