Nonsustained ventricular tachycardia in severe heart failure. Independent marker of increased mortality due to sudden death. GESICA-GEMA Investigators

Circulation
H C DovalS V Perrone

Abstract

The goal of the study was to determine the prognostic value of nonsustained ventricular tachycardia (NSVT) in total mortality in severe congestive heart failure (CHF) and in death modes. NSVT is associated with an increased mortality in CHF. However, the predictive value of NSVT as a marker for sudden death or death due to progressive heart failure has not been determined. Five hundred sixteen patients from the GESICA trial (33.4% with NSVT) were initially studied with the results of 24-hour Holter and 2 years of follow-up. Within 2 years, 87 of 173 patients (50.3%) with NSVT and 106 of 343 patients (30.9%) without NSVT died. Relative risk (RR) was 1.69 (95% confidence interval [CI], 1.27 to 2.24; P < .0002), and Cox proportional hazard analysis was 1.62 (95% CI, 1.22 to 2.16; P < .001). Sudden death increased from 8.7% (30 of 343) to 23.7% (41 of 173) in patients with NSVT (RR, 2.77; 95% CI, 1.78 to 4.44; P < .001). Progressive heart failure death was also increased from 17.5% (60 of 343) to 20.8% (36 of 173) (P = .22). Quantitative analysis of 24-hour Holter (first 295 patients) demonstrated that couplets had a similar RR to that of NSVT for both total mortality (RR, 1.81; 95% CI, 1.22 to 2.66; P < .002) and sudden death (RR,...Continue Reading

References

Jun 4, 1992·The American Journal of Cardiology·P J PodridT T Fuchs
Aug 10, 1989·The New England Journal of Medicine·UNKNOWN Cardiac Arrhythmia Suppression Trial (CAST) Investigators
Sep 1, 1989·Journal of the American College of Cardiology·A GradmanS Goldstein
Sep 1, 1983·Journal of the American College of Cardiology·J R WilsonM E Josephson

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Citations

Feb 17, 2000·Clinical Cardiology·G V NaccarelliJ C Luck
Oct 20, 2005·Pediatric Cardiology·C T SpencerR M Bryant
Apr 13, 2005·Herzschrittmachertherapie & Elektrophysiologie·G Fröhlig
Nov 5, 2008·Cardiovascular Drugs and Therapy·Savina NodariLivio Dei Cas
Nov 21, 2000·The American Journal of Cardiology·F GaitaL Padeletti
Dec 31, 1997·Journal of the American College of Cardiology·B F Uretsky, R G Sheahan
Jun 17, 2000·Progress in Pediatric Cardiology·C E Canter
Jun 11, 2003·Journal of Consulting and Clinical Psychology·Robert A CarelsWilliam H O'Brien
May 21, 2004·The New England Journal of Medicine·Alan KadishUNKNOWN Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators
Jan 17, 2002·The New England Journal of Medicine·H V HuikuriR J Myerburg
Nov 6, 2004·The Journal of Cardiovascular Nursing·Nancy M Albert
Jan 16, 2002·Cardiology in Review·William G StevensonWilliam H Maisel
Dec 24, 1997·Australian and New Zealand Journal of Medicine·T J Campbell
Apr 6, 2000·Pacing and Clinical Electrophysiology : PACE·A KadishJ Levine
Mar 25, 1998·Journal of Cardiovascular Electrophysiology·J T Vermeulen
Jan 31, 2008·BMC Medical Informatics and Decision Making·John M Darrington, Livia C Hool
Nov 27, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi KiharaChuwa Tei
May 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuyuki ShibaUNKNOWN CHART Investigators
Jun 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira UenoTeruo Takano
Dec 6, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Takanori IkedaHideaki Yoshino
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·J L Merino
Aug 11, 2000·European Journal of Heart Failure·G M De Ferrari, L Tavazzi
Jun 20, 1998·AACN Clinical Issues·C C Ballew, J Reigle
Oct 12, 2004·AACN Clinical Issues·Dulce Obias-Manno, Mevan Wijetunga
Feb 10, 2000·Current Opinion in Cardiology·G V NaccarelliJ C Luck
Aug 18, 2005·Current Cardiology Reports·Frank A Cuoco, Steven N Singh
Mar 30, 2011·Current Cardiology Reports·Michael W FongLeslie Saxon
Aug 25, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Gregory Y H LipIrene Savelieva
Nov 30, 2013·Cardiology Clinics·Liviu Klein, Henry Hsia
Nov 13, 2013·Progress in Cardiovascular Diseases·Demosthenes G KatritsisA John Camm

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