Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

Dentistry Journal
Verônica Oliveira DiasHercílio Martelli Júnior

Abstract

Multiple studies have demonstrated an association between cancer and nonsyndromic oral clefts in different populations. In this study, we assessed the occurrence of nonsyndromic oral clefts in families of patients with acute lymphoblastic leukemia (ALL, n = 50) and controls (n = 125). The parents of the patients answered a questionnaire with basic demographic information and family history of nonsyndromic oral clefts in first-degree relatives. Statistical analysis was carried out using Fisher's exact test. In the ALL group, 22 (44%) were male and 28 (56%) were female, and the average age was 13.2 ± 12.2 years. In the control group, 64 (51.2%) were male and 65 were female and the average age was 11.3 ± 10.3 years. Two out of 50 patients (4%) with acute lymphoblastic leukemia had a positive history of nonsyndromic oral clefts, whereas there were no reported occurrences of nonsyndromic oral clefts in the control group (OR: 12.94, 95% CI: 0.61-274.6, p = 0.08). Despite the limited population, the frequency of nonsyndromic oral clefts was increased in the first-degree relatives of patients with acute lymphoblastic leukemia. Studies with larger samples and molecular analyses are needed to better understand the possible etiological re...Continue Reading

References

Dec 22, 1999·American Journal of Medical Genetics·E F SteinwachsJ T Hecht
Mar 31, 2000·Medical and Pediatric Oncology·M NishiY Hatae
Dec 7, 2007·Brazilian Oral Research·Hercílio Martelli-JuniorRicardo Della Coletta
Dec 13, 2007·Cancer·Amy M Linabery, Julie A Ross
Apr 17, 2008·Human Molecular Genetics·Brett T ChiquetJacqueline T Hecht
Jul 16, 2008·Pharmaceutical Research·Preetha AnandBharat B Aggarwal
Jan 3, 2009·The Journal of the American Dental Association·Renato MenezesAlexandre Rezende Vieira
Jan 10, 2009·Journal of Dental Research·L MengJ W Von den Hoff
Jun 3, 2009·Brazilian Oral Research·Katamara RodriguesMaria Angela Fernandes Ferreira
Feb 19, 2011·Nature Reviews. Genetics·Michael J DixonJeffrey C Murray
Oct 25, 2011·International Journal of Cancer. Journal International Du Cancer·Irma KluijtUNKNOWN Dutch Working Group on Hereditary Gastric Cancer
Nov 1, 2011·Annals of Epidemiology·Alexander DietzKaare Christensen
Feb 4, 2012·American Journal of Medical Genetics. Part a·Aditi Jindal, Alexandre R Vieira
Apr 13, 2012·Journal of Dental Research·M YildirimA R Vieira
May 16, 2012·American Journal of Medical Genetics. Part a·Alexandre R VieiraBaiba Lace
Nov 6, 2012·International Journal of Cancer. Journal International Du Cancer·Patrick R BenusiglioDavid Malka
Jun 19, 2013·PloS One·Gerson Shigeru KobayashiMaria Rita Passos-Bueno
Aug 24, 2013·Brazilian Dental Journal·Leonardo Santos LimaHercílio Martelli-Júnior
Nov 22, 2013·American Journal of Medical Genetics. Part a·Daniella Reis Barbosa MartelliHercílio Martelli-Júnior
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 23, 2014·Brazilian Oral Research·Eduardo GonçalvesHercílio Martelli
Oct 16, 2015·The New England Journal of Medicine·Stephen P Hunger, Charles G Mullighan
Oct 29, 2015·American Journal of Medical Genetics. Part a·Renato Assis MachadoRicardo D Coletta
Dec 24, 2017·Medicina oral, patología oral y cirugía bucal·E-F CardosoH Martelli-Júnior
Dec 24, 2018·Archives of Oral Biology·Edimilson Martins de FreitasHercílio Martelli-Júnior

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
D F WyszynskiRicardo D Bennun
American Journal of Medical Genetics. Part a
C ChevrierS Cordier
American Journal of Medical Genetics. Part a
Antonio Richieri-Costa, Maria Leine Guion-Almeida
The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
Yah-Huei Wu-ChouLun-Jou Lo
© 2021 Meta ULC. All rights reserved