Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress I: Effects in males and females

Psychoneuroendocrinology
Bradley M Avery, Suzanne Vrshek-Schallhorn

Abstract

Genetic influences on stress reactivity may provide insight into depression risk mechanisms. The C-allele of rs6318, a putatively functional polymorphism located within the HTR2C gene, has been reported to predict greater cortisol and negative affective reactivity to lab-induced stress. However, the potential moderating effect of sex has not been examined despite X-linkage of HTR2C. We hypothesized that sex moderates the effect of rs6318 on cortisol and affective reactivity to lab-induced stress, with males showing stronger effects. Non-depressed young adults (N=112; 39 female) screened via clinical interview provided a DNA sample and completed either a negative evaluative Trier Social Stress Test, or a non-evaluative control protocol. Salivary cortisol and self-reported affect were assessed at four timepoints. Contrary to hypotheses, C-carriers showed blunted rather than exaggerated cortisol responses to lab-induced stress in multilevel models (b=0.467, p<0.001), which persisted when covarying subclinical depressive symptoms. This effect was not moderated by sex (b=0.174, p=0.421), and remained significant when examining females (b=0.362, p=0.013) and males (b=0.537, p<0.001) separately. C-carriers also exhibited marginally gr...Continue Reading

References

Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R A DressendörferC J Strasburger
Dec 1, 1991·Biological Psychiatry·R S Kahn, S Wetzler
Jun 1, 1988·Journal of Personality and Social Psychology·D WatsonA Tellegen
Jan 19, 1999·Archives of General Psychiatry·K S Kendler, C A Prescott
Dec 24, 2003·Journal of Clinical Psychology·Mark ZimmermanDiane Young
Oct 29, 2004·Journal of Personality·Sally S DickersonMargaret E Kemeny
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ilona S FederenkoStefan Wüst
Jun 18, 2005·Psychoneuroendocrinology·Heather M BurkeDavid C Mohr
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lynn M OswaldGary S Wand
Oct 24, 2006·Physiology & Behavior·Ari LevineAron Weller
Apr 11, 2007·Psychosomatic Medicine·Petra H WirtzUlrike Ehlert
Apr 25, 2007·Genes, Brain, and Behavior·L K HeislerL H Tecott
Jun 29, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lora K HeislerLaurence H Tecott
Dec 11, 2007·Pharmacology, Biochemistry, and Behavior·Katsuya HaradaNobuya Matsuoka
Jun 7, 2008·Neuroscience and Biobehavioral Reviews·Laurence LanfumeyMichel Hamon
Jul 9, 2008·Psychosomatic Medicine·Peggy M ZoccolaFrank P Zaldivar
Oct 16, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Eva FriesClemens Kirschbaum
Oct 22, 2008·Psychoneuroendocrinology·Andrew SteptoeJane Wardle
Jul 30, 2010·Stress : the International Journal on the Biology of Stress·Peggy M ZoccolaIlona S Yim
Sep 18, 2010·Current Psychiatry Reports·Falk W Lohoff
Apr 5, 2012·Molecular Psychiatry·UNKNOWN Major Depressive Disorder Working Group of the Psychiatric GWAS ConsortiumPatrick F Sullivan
Dec 3, 2014·Biological Psychology·Beverly H BrummettRedford B Williams

❮ Previous
Next ❯

Citations

Oct 23, 2019·Hormones and Behavior·Matias M PulopulosRudi De Raedt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.