Nonsystemic vasculitic mononeuropathy multiplex, cryoglobulinemia, and hepatitis C

Muscle & Nerve
W S DavidS A Smith

Abstract

A 39-year-old man developed sequential acute mononeuropathies involving both median, both ulnar, and the right radial and left peroneal nerves. Electrophysiology demonstrated an asymmetric sensorimotor axonal polyneuropathy; nerve biopsy confirmed a vasculitis. Laboratory evaluation revealed a mixed cryoglobulinemia and active hepatitis C infection. The patient stabilized with prednisone/cyclophosphamide/interferon-alpha. Hepatitis C should be considered in the differential diagnosis of mononeuropathy multiplex. Accurate diagnosis is important, as interferon-alpha may prevent transition to chronic hepatitis/cirrhosis.

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Citations

Feb 17, 2001·Muscle & Nerve·R Rosenbaum
Feb 27, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J CostaM de Carvalho
Dec 11, 1999·Current Opinion in Neurology·Z Simmons
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Apr 8, 2021·Reviews on Recent Clinical Trials·Nicola IelapiRaffaele Serra

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