Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid

Case Reports in Oncological Medicine
Carsten NiederTerje Tollåli

Abstract

Purpose. To describe tumor shrinkage of nonirradiated lung metastases in a patient with non-small cell lung cancer. Case Report. The patient had a concurrent autoimmune condition, bullous pemphigoid, which was clinically exacerbated during radiotherapy of mediastinal and axillary lymph node metastases. He also developed a series of infections during and after irradiation, and we hypothesize that the immunological events during this phase might have influenced the size of the nonirradiated metastases. Conclusion. Ionizing radiation generates inflammatory signals and, in principle, could provide both tumor-specific antigens from dying cells and maturation stimuli that are necessary for dendritic cells' activation of tumor-specific T cells. Even if the detailed mechanisms causing nontargeted immune modulatory effects in individual patients are poorly understood, clinical development of radioimmunotherapy is underway.

References

Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Feb 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenshiro ShiraishiShiro Kanegasaki
May 31, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C SchröderA Buchali
Jan 15, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·B van OorschotM Flentje
Feb 25, 2014·Cancer Immunology Research·Encouse B GoldenSilvia C Formenti

❮ Previous
Next ❯

Citations

Nov 8, 2016·La Presse médicale·Nicolas KlugerPauliina Nuutinen
Oct 15, 2020·Biomolecules·Francesco MoroGiovanni Di Zenzo

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Sandra DemariaSilvia C Formenti
Proceedings of the National Academy of Sciences of the United States of America
William F Morgan, Marianne B Sowa
The Keio Journal of Medicine
L A DiazY Takahashi
Archives of Biochemistry and Biophysics
R Iyer, B E Lehnert
© 2021 Meta ULC. All rights reserved