Abstract
Cardiovascular biomarkers such as N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin T (cTnT), hs-CRP (high sensitivity C-reactive protein), and albuminuria predict underlying heart disease in the general population as well as CKD patients. We aimed to study the association of NT-proBNP, cTnT, hs-CRP, and spot urine albumin creatinine ratio with carotid intima media thickness (CIMT) for cardiovascular risk estimation in predialysis CKD (chronic kidney disease) patients. This cross-sectional study included a total of 120 adult predialysis CKD patients. Forty patients were allocated in each predialysis CKD group of stages 3, 4, and 5. Serum cTnT and hs-CRP, plasma NT-proBNP, and single spot urine albumin creatinine ratio (ACR) were measured. Ultrasonographic examination of carotid artery was done with 7.5 MHz linear probe in B mode ultrasonography and carotid intima media thickness was measured. Mean values ± standard deviation of plasma NT-proBNP (pg/mL), serum hs-CRP (mg/L), spot urine ACR (mg/g of creatinine), and CIMT (mm) were 585.68 ± 514.84, 5.96 ± 2.52, 719.37 ± 411.36, and 0.78 ± 0.15, respectively in predialysis CKD patients (n = 120). Serum cTnT level was high in 40% of predialysis CKD patients. Am...Continue Reading
References
Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J T Salonen, R Salonen
Oct 1, 1990·Circulation·T E CravenJ R Crouse
Jan 1, 1995·Kidney International·R N FoleyP E Barre
May 1, 1994·Journal of Internal Medicine·G GeroulakosA G Shaper
Sep 18, 1997·American Journal of Epidemiology·L E ChamblessL X Clegg
Feb 21, 1998·Annals of Internal Medicine·H N HodisS P Azen
Mar 13, 1999·Annals of Internal Medicine·A S LeveyD Roth
Dec 8, 1997·Journal of Insurance Medicine·M Moore
May 20, 1999·Diabetes Care·A J Bakker
Jun 21, 2001·The Journal of Clinical Hypertension·G L Bakris
Jul 19, 2002·The New England Journal of Medicine·Kenneth L Baughman
Jul 19, 2002·The New England Journal of Medicine·Alan S MaiselUNKNOWN Breathing Not Properly Multinational Study Investigators
Jul 26, 2002·Nephron·Vincenzo PanichiR Colombo
Jan 29, 2003·Circulation·Thomas A PearsonUNKNOWN American Heart Association
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yoshiki NishizawaMasaaki Inaba
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Aug 2, 2003·Lancet·James A de LemosMark H Drazner
Sep 13, 2003·Kidney International·Akihiko KatoAkira Hishida
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Martin J LandrayColin Baigent
Jun 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christopher R DeFilippiRobert Christenson
Jul 15, 2005·Kidney International·Vandana MenonMark J Sarnak
Jul 29, 2005·Artificial Organs·Robert EkartBreda Pecovnik Balon
Sep 17, 2005·Clinical Chemistry·Nasir A AbbasEdmund J Lamb
Apr 6, 2006·Clinical Medicine & Research·Huseyin BozbasHaldun Muderrisoglu
May 16, 2006·Heart·Michael Weber, Christian Hamm
Aug 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew A RobertsFrancesco L Ierino
May 15, 2007·Journal of the American Society of Nephrology : JASN·Cheuk-Chun SzetoPhilip Kam-Tao Li
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·Angela Yee-Moon Wang, Kar-Neng Lai
Aug 9, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Akshay S DesaiMarc A Pfeffer
Feb 16, 2012·International Journal of Nephrology and Renovascular Disease·Hernán TrimarchiMirta Alonso
Apr 5, 2012·Kidney & Blood Pressure Research·Yasar CaliskanSemra Bozfakioglu