PMID: 16527072Mar 11, 2006Paper

Nonvaccine Streptococcus pneumoniae serotypes causing acute bacterial meningitis

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
A Luque MorenoJ Macià Martí

Abstract

The pneumococcal heptavalent conjugate vaccine protects children aged less than 2 years old from invasive pneumococcal disease (IPD). Efficacy is 89-93% in the US population and 71-86% in European studies. The vaccine confers active immunization against the main serotypes causing IPD (4, 6B, 9V, 14, 18C, 19F y 23F). We describe 2 children who presented with pneumococcal meningitis caused by nonvaccine serotypes. As a result of the widespread use of the heptavalent vaccine, there may be a shift in the serotypes causing IPD.

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