PMID: 3215198Dec 1, 1988Paper

Noonan syndrome: growth and clinical manifestations in 144 cases

European Journal of Pediatrics
Michael B RankeJ R Bierich

Abstract

We have analysed growth and the major clinical manifestations of 144 patients (89 males, 55 females) with Noonan syndrome from two West German centres. Size at birth was normal in both sexes. In both males and females, the mean height followed along the 3rd per centile until puberty, but decreased transiently due to an approximately 2 year delay in onset of puberty. Final height approaches the lower limits of normal at the end of the 2nd decade of life. The mean adult height was found to be (n = 20) 162.5 cm in males and (n = 13) 152.7 cm in females, respectively. Smoothed means and standard deviations for height were derived. These data may be used for the statistical evaluation of height of Noonan syndrome patients. Except for mental retardation and microcephaly, which are more frequent in males, the relative frequencies of minor anomalies and malformations were found to be similar in both sexes. The characteristic non-cyanotic heart defects in the Noonan syndrome do not appear to have a major influence on growth. The auxological data were compared with those in the Ullrich-Turner syndrome.

References

Jan 1, 1979·American Journal of Medical Genetics·J M Opitz, P D Pallister
Aug 1, 1979·American Journal of Diseases of Children·J Money, M E Kalus
Jan 1, 1987·Journal of Medical Genetics·J E Allanson
Sep 1, 1986·Clinical Genetics·D R WittJ E Allanson
Jul 1, 1985·American Journal of Medical Genetics·H M Mendez, J M Opitz
Jul 1, 1985·American Journal of Medical Genetics·J E AllansonR D Witt
Dec 1, 1973·The Journal of Pediatrics·E Collins, G Turner
Oct 1, 1968·American Journal of Diseases of Children·J A Noonan
Jan 1, 1974·American Journal of Diseases of Children·J J NoraH A Lubs
Oct 1, 1968·American Journal of Diseases of Children·J J Nora, A K Sinha
Jan 1, 1969·The Journal of Pediatrics·R L Summitt
Dec 1, 1983·European Journal of Pediatrics·M B RankeF Majewski
Apr 1, 1983·Pediatric Cardiology·L C BliedenH N Neufeld
Jan 1, 1981·American Journal of Medical Genetics·W J DuncanR D Rowe

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Citations

Jan 1, 1996·Ryōikibetsu shōkōgun shirīzu·J Fukushige
Dec 21, 2006·Reviews in Endocrine & Metabolic Disorders·Jacqueline A Noonan
Oct 6, 1998·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J M LimalS Lyonnet
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Audrey De Rocca Serra-NédélecArmelle Yart
Oct 6, 2005·Acta Paediatrica·Deborah OsioOtto Westphal
Jun 28, 2006·Acta Paediatrica. Supplement·Marco CappaPaola Cambiaso
Jun 15, 2004·Clinical Dysmorphology·Yasemin AlanaySeza Ozen
Feb 1, 1996·Acta Paediatrica Japonica; Overseas Edition·T Tanaka
Jul 13, 2012·Genes, Brain, and Behavior·E WingbermühleJ I M Egger
Oct 1, 1993·Acta Paediatrica·B C Thomas, R Stanhope
Sep 23, 2006·Archives of Disease in Childhood·A C ShawM A Patton
Jan 6, 1999·Archives of Disease in Childhood·J MulliganP R Betts
Apr 24, 2001·Archives of Disease in Childhood·J M Kirk Group tU
Jun 1, 1994·Journal of Medical Genetics·M M ElsawiM A Patton
Jul 22, 2010·Molecular Syndromology·M TartagliaB D Gelb
Jan 16, 2007·Orphanet Journal of Rare Diseases·Ineke van der Burgt
Feb 25, 2006·The Tohoku Journal of Experimental Medicine·Ikuko TakahashiAkio Koizumi
Jun 22, 2005·Treatments in Endocrinology·Chris J H Kelnar
Apr 25, 2000·Indian Journal of Pediatrics·A T SolimanM A Fattah
Dec 13, 1997·Annals of Human Biology·L T Rekers-MombargJ M Wit
Sep 6, 2015·European Journal of Medical Genetics·Mylène TajanArmelle Yart
Oct 27, 2012·Endocrinology and Metabolism Clinics of North America·Elizabeth ChackoRobert Rapaport
Dec 10, 2015·Pediatric Research·Tsuyoshi IsojimaSusumu Yokoya
Oct 25, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anne-Marie Kappelgaard, Torben Laursen
Jul 9, 2011·Advances in Pediatrics·Bradley S Miller
Aug 17, 2010·Nutrition·Koen F M Joosten, Jessie M Hulst
Jan 22, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·T EdouardM Tauber
Jun 17, 2003·Clinical Endocrinology·Christopher J H Kelnar
Mar 12, 2008·Clinical Endocrinology·Lize V FerreiraAlexander A L Jorge
Aug 14, 2012·American Journal of Medical Genetics. Part a·Alexsandra C MalaquiasAlexander A L Jorge
Oct 15, 2013·American Journal of Medical Genetics. Part a·Laura MazzantiMarco Tartaglia
Oct 1, 1992·Current Problems in Pediatrics·J A Grunt, I D Schwartz
Oct 9, 2015·Italian Journal of Pediatrics·Niki ZavrasMauro Bozzola
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·M B Ranke
Sep 12, 2015·Current Problems in Pediatric and Adolescent Health Care·Stacy L MeyerSusan Almazan
Mar 9, 2004·Endocrine Journal·Masamichi OgawaMasaaki Yoshimoto
Apr 13, 2012·The Journal of Pediatrics·Gerhard BinderThomas Paul
Jan 23, 2014·Reumatología clinica·Lina Maria Saldarriaga RiveraBlanca Elena Rios Gomes Bica
Feb 24, 2016·European Journal of Endocrinology·Catie CessansThomas Edouard
Feb 23, 2011·Arquivos brasileiros de endocrinologia e metabologia·Amanda Salem BrasilDébora Romeo Bertola

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