NOP agonists prevent the antidepressant-like effects of nortriptyline and fluoxetine but not R-ketamine

Psychopharmacology
Victor A D HolandaElaine C Gavioli

Abstract

Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of a Gi protein-coupled receptor named NOP. Both N/OFQ and NOP receptor are widely expressed in brain areas involved in the control of emotional processes. Clinical and preclinical studies support antidepressant effects due to the blockade of NOP receptor signaling. By contrast, NOP receptor activation did not evoke any change in behavioral despair tests. The present study aimed to investigate the effects of the co-administration of NOP agonists and classic antidepressant drugs in the forced swimming test (FST) and learned helplessness model (LH) in mice. Male Swiss mice were co-administered with NOP agonists (N/OFQ and Ro 65-6570) and antidepressants (nortriptyline, fluoxetine, and R-ketamine) or SB-612111 (NOP antagonist) and the behavioral effects were assessed in the FST and LH tests. Fluoxetine, nortriptyline, R-ketamine and the NOP antagonist SB-612111 displayed antidepressant-like effects in the FST. The administration of the NOP agonists N/OFQ and Ro 65-6570 did not induce any behavioral change. However, co-administration of NOP agonists blocked the antidepressant effects of SB-612111, fluoxetine, and nortriptyline, but not R-ketamine in the FST. Similarly, in the ...Continue Reading

References

Jan 1, 1981·Progress in Neuro-psychopharmacology·J I TelnerY D Lapierre
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·C MollereauM Parmentier
Dec 1, 1996·British Journal of Pharmacology·M ConnorM J Christie
Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Sep 22, 2000·Peptides·C Mollereau, L Mouledous
Feb 24, 2001·Naunyn-Schmiedeberg's Archives of Pharmacology·E HashibaD G Lambert
Jan 31, 2002·Naunyn-Schmiedeberg's Archives of Pharmacology·John P RedrobeRémi Quirion
Apr 2, 2002·Neuroreport·Catherine VilpouxIsabelle Leroux-Nicollet
Jun 16, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·E C GavioliG Calo'
Feb 24, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Elaine C Gavioli, Girolamo Calo'
Aug 9, 2006·Archives of General Psychiatry·Carlos A ZarateHusseini K Manji
Jul 24, 2010·British Journal of Pharmacology·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Dec 28, 2010·Neuropharmacology·Anna RizziGirolamo Calo'
Nov 15, 2011·Stress : the International Journal on the Biology of Stress·Paola NativioFrancesca Passarelli
May 5, 2012·Nature Protocols·David A Slattery, John F Cryan
Mar 5, 2013·Psychopharmacology·Valentina GigliucciAndrew Harkin
May 29, 2013·Pharmacology & Therapeutics·Elaine Cristina Gavioli, Girolamo Calo'
Nov 6, 2013·Pharmacology & Therapeutics·Jeffrey M WitkinRoberto Ciccocioppo
Aug 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kenichi FukumotoShigeyuki Chaki
Nov 21, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anke PostJeffrey M Witkin
Jan 18, 2017·Pharmacology Research & Perspectives·Jeffrey M WitkinMichael A Statnick

❮ Previous
Next ❯

Citations

Jul 25, 2019·Journal of Psychopharmacology·Victor A D HolandaChiara Ruzza
Oct 4, 2019·Nature Reviews. Neuroscience·Anand GururajanDavid A Slattery
Nov 5, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jong Yung ParkKyung Ho Shin
Feb 26, 2020·Psychopharmacology·Aldemara I SilvaElaine C Gavioli
Jun 24, 2020·Peptides·Richard J Bodnar

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

ARRIVE
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.