Noradrenaline activates the NO/cGMP/ATP-sensitive K(+) channels pathway to induce peripheral antinociception in rats

Nitric Oxide : Biology and Chemistry
Thiago R L RomeroIgor Dimitri Gama Duarte

Abstract

Despite the classical peripheral pronociceptive effect of noradrenaline (NA), recently studies showed the involvement of NA in antinociceptive effect under immune system interaction. In addition, the participation of the NO/cGMP/KATP pathway in the peripheral antinociception has been established by our group as the molecular mechanism of another adrenoceptor agonist xylazine. Thus the aim of this study was to obtain pharmacological evidences for the involvement of the NO/cGMP/KATP pathway in the peripheral antinociceptive effect induced by exogenous noradrenaline. The rat paw pressure test was used, with hyperalgesia induced by intraplantar injection of prostaglandin E(2) (2μg/paw). All drugs were locally administered into the right hind paw of male Wistar rats. NA (5, 20 and 80ng/paw) elicited a local inhibition of hyperalgesia. The non-selective NO synthase inhibitor l-NOarg (12, 18 and 24μg/paw) antagonized the antinociception effect induced by the highest dose of NA. The soluble guanylyl cyclase inhibitor ODQ (25, 50 and 100μg/paw) antagonized the NA-induced effect; and cGMP-phosphodiesterase inhibitor zaprinast (50μg/paw) potentiated the antinociceptive effect of NA low dose (5ng/paw). In addition, the local effect of NA w...Continue Reading

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Feb 25, 2009·European Journal of Pharmacology·Thiago Roberto Lima RomeroIgor Dimitri Gama Duarte

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Citations

Mar 31, 2015·Life Sciences·Lívia Caroline Resende SilvaThiago Roberto Lima Romero
Jun 26, 2018·Pharmacological Reports : PR·Thiago Roberto Lima RomeroIgor Dimitri Gama Duarte
Jun 19, 2019·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Ting WuMeichun Deng
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gustavo Henrique Ferreira GonçalinhoAntonio de Padua Mansur

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