PMID: 9175604May 2, 1997Paper

Noradrenaline activates vasopressin neurons via alpha1-receptor-mediated Ca2+ signaling pathway

Neuroscience Letters
S ShiodaY Nakai

Abstract

Noradrenaline (NA) (1-10 microM), dibutyryl-cAMP (1-5 mM), and forskolin (10-20 microM) increased cytosolic Ca2+ concentration ([Ca2+]i) in isolated arginine-vasopressin (AVP)-containing neurons in the hypothalamic supraoptic nucleus (SON). The NA-induced increase in [Ca2+]i in AVP-containing neurons was abolished by a specific alpha1-antagonist, prazosin (1 microM) and was markedly reduced when treated with a protein kinase A (PKA) blocker, H89 (40 microM). The NA-induced [Ca2+]i was not altered by a protein kinase C (PKC) inhibitor, calphostin C (0.1 microM) and a PKC activator, TPA (100 nM). In general, NA, a known neurotransmitter in the SON, activates AVP-containing neurons via alpha1-receptor which is linked to stimulation of cAMP-PKA-regulated Ca2+ signaling pathway.

References

Sep 21, 1989·Nature·M J Berridge, R F Irvine

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Citations

Apr 4, 1998·Neuroscience Research·S ShiodaY Nakai
May 13, 1999·Neuroscience Letters·S MuroyaM Takigawa
Feb 3, 1999·Annals of the New York Academy of Sciences·S ShiodaA Arimura
Mar 28, 2008·The European Journal of Neuroscience·N MaoloodV Grange-Messent
Mar 8, 2008·Reproduction in Domestic Animals = Zuchthygiene·S P S GhumanH Dobson
Dec 9, 2008·Autonomic Neuroscience : Basic & Clinical·Cristiane BusnardoFernando Morgan Aguiar Corrêa
Feb 16, 2006·Journal of Neuroscience Research·Victoria I MelnikovaValerie Grange-Messent
Jan 28, 2010·American Journal of Physiology. Endocrinology and Metabolism·Kristy IskandarJun Nakae
Feb 24, 2001·Annals of the New York Academy of Sciences·S ShiodaH Funahashi

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