Abstract
To explore the role of hepatic sympathetic nerves on the secretion of very low density lipoprotein (VLDL), the effects of sympathetic neurotransmitters, noradrenaline and ATP, on the secretion of triglyceride and apoprotein B (ApoB) from the liver were studied using rat liver perfused in situ with recirculation. During liver perfusion with physiological medium, the amount of triglyceride in the perfusate was increased linearly for up to 120 min. The addition of noradrenaline to the perfusion medium at a final concentration of 1 muM increased the portal pressure and suppressed the secretion of triglyceride to about 60% of control without an increase in free fatty acid production. The administration of ATP increased the portal pressure with kinetics different from those induced by noradrenaline, but suppressed the triglyceride secretion to an extent similar to that induced by noradrenaline. The suppressive effect of noradrenaline on triglyceride secretion was mimicked by an alpha-adrenoceptor agonist, phenylephrine, and was retained after the haemodynamic changes were prevented by sodium nitroprusside. The secretion of ApoB from the perfused liver was also inhibited by noradrenaline or ATP to about 70% of control. However, hepati...Continue Reading
Citations
Jun 20, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Paul Ernsberger, Richard J Koletsky
Jun 5, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Richard Browning
Jun 24, 2011·PloS One·Alessandro MarsiliAnn Marie Zavacki
Sep 27, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Eveline BruinstroopAndries Kalsbeek
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Gerhard P Püschel
Apr 18, 2009·Toxicology and Applied Pharmacology·Naida YinZhan Yin
Nov 26, 2008·Aquatic Toxicology·Liwen MaZhan Yin
Jun 11, 2008·Cell Biochemistry and Function·Fábio Luís Tavares, Marília Cerqueira Leite Seelaender
Oct 19, 2004·Atherosclerosis·Luis C L CorreiaAndrei C Spósito
Sep 16, 2011·Autonomic Neuroscience : Basic & Clinical·Rafik HachaniKamel Kacem
Feb 14, 2015·Biochimica Et Biophysica Acta·J SchleicherS Schuster
May 12, 2007·Neurochemistry International·Geoffrey Burnstock
Jan 12, 2010·Biochimica Et Biophysica Acta·Chun-Xia YiAndries Kalsbeek
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·G L Plaa
Jul 6, 2016·Wiener klinische Wochenschrift·Péter KoncsosGyörgy Paragh
Mar 28, 2017·PloS One·Michael F La FountaineWilliam A Bauman
Apr 22, 2017·The Journal of Endocrinology·Caroline E Geisler, Benjamin J Renquist
Dec 20, 2017·Nutrition & Diabetes·Simona BoMauro Maccario
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Aug 12, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Frank M Bengel
Mar 27, 2018·Obesity·Virginia LópezNilda Gallardo
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·D V ChirieacJ D Sparks
Jul 3, 2021·International Journal of Molecular Sciences·Flaminia FerriStefano Ginanni Corradini
Aug 1, 2006·European Journal of Pharmacology·Mehdi Rasouli, Mahin Zahraie
Dec 3, 2016·Current Opinion in Lipidology·Jennifer TaherKhosrow Adeli