PMID: 5087068Oct 1, 1972Paper

Noradrenaline concentration and turnover in different regions of the gastrointestinal tract of the rat: an approach to the evaluation of sympathetic activity in the gut

Gut
H L TaubinL Landsberg

Abstract

The endogenous noradrenaline concentration, fractional turnover, half-life, and turnover rate of tritiated ((3)H) noradrenaline were determined in the oesophagus, non-glandular and glandular portions of the stomach, duodenum, jejunum, ileum, and colon of the rat. The highest concentration of endogenous noradrenaline was present in the duodenum and colon. The (3)H-noradrenaline fractional turnover rates and half-lives were significantly greater in the small and large intestines as compared with the oesophagus and stomach. The noradrenaline turnover rate, which is an estimate of the level of sympathetic activity, was greatest in the colon and duodenum. This method of assessing sympathetic activity in various tissues by direct measurement of the noradrenaline turnover rate may be applied to the study of the adrenergic nervous system in the physiology and pathophysiology of the gastrointestinal tract.

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Citations

May 1, 1977·Journal of Clinical Pharmacology·F LechinF Peña
May 18, 2006·Cellular and Molecular Neurobiology·Lewis Landsberg
Dec 1, 1992·Journal of the Autonomic Nervous System·M Iwai, T Shimazu
Sep 12, 1996·Journal of the Autonomic Nervous System·M A GarofaloR H Migliorini
Jan 1, 1983·Neurochemistry International·C LegayJ P Ternaux
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·F VillarroyaT Mampel
Jul 22, 1998·Journal of the Autonomic Nervous System·M N BritoR H Migliorini
May 1, 1980·The Journal of Clinical Investigation·J B Young, L Landsberg
May 1, 1982·The Journal of Clinical Investigation·J B YoungL Landsberg
May 1, 1983·The Journal of Clinical Investigation·T S JohnsonL Landsberg
Sep 1, 1983·The Journal of Clinical Investigation·T YoshidaG A Bray
Jul 22, 2008·Canadian Journal of Physiology and Pharmacology·Valéria E ChavesRenato H Migliorini
Apr 1, 1985·Journal of Pharmacological Methods·Y RuckebuschA L Blum
Nov 1, 1984·Metabolism: Clinical and Experimental·T YoshidaM Kondo
Feb 1, 1982·Metabolism: Clinical and Experimental·E B RappaportL Landsberg
Jan 1, 1987·Metabolism: Clinical and Experimental·T YoshidaM Kondo
Jan 1, 1986·Journal of Pineal Research·M ViswanathanJ C George
Nov 15, 1973·Biochemical Pharmacology·L Landsberg, H L Taubin
Feb 4, 1998·Obesity Research·J B Young, L Landsberg
Nov 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kesinee Netsomboon, Andreas Bernkop-Schnürch
Feb 4, 2014·Colloids and Surfaces. B, Biointerfaces·Lay Hong ChuahRozita Rosli
Jul 6, 2004·Journal of Ethnopharmacology·Poonam DharmaniGautam Palit
Dec 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·James B YoungLewis Landsberg
Nov 15, 1993·Experientia·E Jauregui
Aug 1, 1995·International Journal of Biometeorology·G R McGregor
Oct 31, 2013·American Journal of Physiology. Endocrinology and Metabolism·Flávia A GraçaLuiz C C Navegantes
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N H KawashitaR H Migliorini
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James B YoungNadine Boufath
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J B Young
Apr 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·William T FestucciaYves Deshaies

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