Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors

Nature
J D LevineJ K Tam

Abstract

In hyperalgesic states, observed commonly as a major symptom of tissue inflammation or after central or peripheral nerve injury, non-noxious stimuli produce pain and noxious stimuli are perceived as more painful than usual. The mechanisms underlying the generation of hyperalgesia are not known. In patients with causalgia (burning pain and severe hyperalgesia after a nerve injury) activation of sympathetic post-ganglionic neurones or application of noradrenaline to painful skin exacerbates pain and hyperalgesia while sympathectomy may afford complete relief. One suggestion is that noradrenaline released from sympathetic post-ganglionic neurons increases the discharge of damaged small-diameter afferents by a direct action on the primary afferents. Here we present a new model for noradrenaline-sensitive hyperalgesia and demonstrate that the site of action of noradrenaline is not on the primary afferents but rather is presynaptic on the sympathetic post-ganglionic terminals.

References

Oct 1, 1977·Physiological Reviews·T C Westfall
Jul 1, 1978·Prostaglandins·S H FerreiraM S de Abreu Castro
Jul 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·L Loh, P W Nathan
Mar 1, 1975·The Journal of Investigative Dermatology·M J FitzGeraldT M O'Brien
Dec 1, 1972·Acta Physiologica Scandinavica·L Stjärne
Sep 1, 1971·British Journal of Pharmacology·G BurnstockM Wright
Dec 1, 1984·Pain·H Blumberg, W Jänig
Mar 1, 1983·Journal of the Autonomic Nervous System·M Devor

❮ Previous
Next ❯

Citations

Oct 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D J Tracey, J S Walker
Jun 5, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·P D Drummond
Oct 13, 2006·European Journal of Applied Physiology·Magda Passatore, Silvestro Roatta
Mar 17, 2001·Current Pain and Headache Reports·R Baron, G Wasner
Sep 5, 2002·Current Pain and Headache Reports·Brian Freund, Marvin Schwartz
Jan 24, 1995·European Journal of Pharmacology·A K Ouseph, J D Levine
Jan 1, 1992·Life Sciences·J L Junien, J G Wettstein
Jul 5, 1996·Journal of the Autonomic Nervous System·Y TsujiiT Kumazawa
Nov 1, 1991·Trends in Pharmacological Sciences·M Koltzenburg, S B McMahon
Jan 1, 1993·Agents and Actions. Supplements·K M HargreavesJ Q Swift
Dec 9, 1991·Neuroscience Letters·J A Vallin, W S Kingery
Dec 24, 1993·Neuroscience Letters·J SatoT Kumazawa
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Jan 1, 1990·Neuroscience·Y O Taiwo, J D Levine
Jan 1, 1992·Neuroscience·Y O Taiwo, J D Levine
Mar 1, 1994·Neuroscience·R SchuligoiR Amann
Jun 17, 1998·Life Sciences·S K SauerP W Reeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.