PMID: 9169306Apr 1, 1997Paper

Noradrenaline in basic models of depression

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
B E Leonard

Abstract

This review reports anatomical studies evaluating central and peripheral alpha 2- and beta-adrenoceptors. The results suggest abnormalities exist in the noradrenergic system in depressed patients. Most animal models involve the use of stress to simulate depression in man. All models that have been developed lead to differential changes in noradrenergic function. We have assessed the effects of reboxetine, a novel, selective noradrenaline-reuptake inhibitor (NARI) in olfactory bulbectomised rats, a procedure that induces significant changes in amygdala function. Reboxetine is an effective antidepressant in the forced swim test and open field test in bulbectomised rats. Unlike the tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), reboxetine is ineffective in the 8-OH-DPAT hypothermia test, indicating that reboxetine is selective for the noradrenergic system. Owing to the abnormalities that occur in depression, it would seem sensible to target the noradrenergic system for treatment of this condition.

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Citations

Apr 3, 2004·Physiology & Behavior·Cher V MasiniGaylen L Edwards
Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Abdalla Salem Elhwuegi
Sep 25, 1999·European Journal of Pharmacology·T J ConnorB E Leonard
Sep 5, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·N BrunelloG Racagni
Apr 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S A Montgomery
Apr 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·I Hindmarch
Jul 14, 2011·Neuropsychiatric Disease and Treatment·Siegfried KasperAlexandra Kutzelnigg
Oct 19, 2010·Physiology & Behavior·Li-Tao YiCun-Cang Cui
Dec 5, 2009·Depression and Anxiety·Andrew W GoddardAnantha Shekhar
Mar 17, 2015·Life Sciences·Silvia Laura Guzmán-GutiérrezRicardo Reyes-Chilpa
Jun 2, 2009·Brain Research Reviews·Kenji Hashimoto
Aug 25, 2016·Physiology & Behavior·Hyungwoo Nam, Ilan A Kerman
Apr 6, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·E V PopkovaT E Iordanskaia
Mar 10, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·I BurcescuUNKNOWN International Consortium for Childhood-Onset Mood Disorders
Aug 13, 2002·Journal of Clinical Psychopharmacology·Vittorino AndreoliMarcio Versiani
Jul 20, 2002·Medicine and Science in Sports and Exercise·Maria Francesca PiacentiniKenny De Meirleir
Sep 26, 2003·Psychosomatic Medicine·Susan S GirdlerKathleen C Light
Jan 26, 2005·Acta Psychiatrica Scandinavica·G S MalhiJ Greenwood
Apr 29, 2018·Neuroscience and Biobehavioral Reviews·E A Kelly, J L Fudge

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