Noradrenaline Reuptake Inhibition Impairs Cortical Output and Limits Endurance Time

Medicine and Science in Sports and Exercise
Malgorzata KlassBart Roelands

Abstract

To assess the neural mechanisms that limit endurance time, we compared a fatiguing task performed under the influence of reboxetine (REB), a noradrenaline reuptake inhibitor, and placebo (PLA). Nine male subjects (age = 24 ± 2 yr) participated in this study. The fatiguing task involved repeated 3-s submaximal isometric contractions of the knee extensors (∼33% maximal voluntary contraction) with a 2-s rest between each contraction and performed until task failure. Before, during, and after exercise, changes in voluntary activation, corticospinal (motor-evoked potential) and spinal excitability (Hoffman reflex), and muscle contractile properties were tested using electrical and transcranial magnetic stimulations. A psychomotor vigilance task assessed reaction time before and after exercise. Compared with PLA, REB reduced the endurance time by 15.6% (P = 0.04). The maximal voluntary contraction torque decreased to a similar extent at task failure in both conditions (P < 0.01), whereas the rate of decline was greater in REB than that in PLA (P = 0.02). The level of voluntary activation tested by transcranial magnetic stimulation and electrical stimulation decreased (P < 0.01) by 10%-15% at the end of the task, but the mean rate of ...Continue Reading

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Citations

Mar 17, 2020·Experimental Physiology·Romain MeeusenBart Roelands
Oct 25, 2016·Medicine and Science in Sports and Exercise·Florian HusmannMartin Behrens
Apr 30, 2017·Medicine and Science in Sports and Exercise·Charlotte J W ConnellNicholas Gant
Mar 21, 2017·European Journal of Sport Science·Romain Meeusen, Bart Roelands
May 5, 2020·Experimental Biology and Medicine·Jenni N IkonenMinna M Tanskanen-Tervo
Mar 24, 2018·Medicine and Science in Sports and Exercise·Malgorzata KlassJacques Duchateau
Dec 9, 2017·European Journal of Applied Physiology·Caroline GirouxNicolas Place
Oct 27, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M S CordeiroD D Soares
Jan 4, 2017·Sports Medicine·Jeroen Van CutsemBart Roelands
Jul 7, 2021·Alimentary Pharmacology & Therapeutics·Jordan J McGingGordon W Moran

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