Noradrenaline spillover during exercise in active versus resting skeletal muscle in man

Acta Physiologica Scandinavica
G SavardB Saltin


Increases in plasma noradrenaline (NA) concentration occur during moderate to heavy exercise in man. This study was undertaken to examine the spillover of NA from both resting and contracting skeletal muscle during exercise. Six male subjects performed one-legged knee-extension so that all measurements could be made both in the exercising and in the resting leg. Subjects exercised for 10 min at each of 50% and 100% of the peak performance capacity of the leg. Leg blood flow was measured by thermodilution and blood samples were drawn for the determination of plasma NA and adrenaline, first in the resting leg and then in the exercising leg. To calculate NA spillover, the extraction of NA (NAe) or of adrenalin (Ae) is required: NAe was measured by repeating the experiment under constant [3H]NA infusion following a 40-min rest period. During exercise, NA spillover was significantly larger in the exercising leg than in the resting leg both during 50% and 100% leg exercise. These results suggest that contracting skeletal muscle may contribute to a larger extent than resting skeletal muscle to increasing the level of plasma NA during exercise. Contractile activity may influence the NA spillover from skeletal muscle by a presynaptic an...Continue Reading


Mar 1, 1975·The Journal of Physiology·R R Lorenz, P M Vanhoutte
Feb 10, 1977·The New England Journal of Medicine·M G ZieglerI J Kopin
Jul 1, 1977·Acta Physiologica Scandinavica·N H SecherJ Trap-Jensen
Jan 1, 1986·Journal of Sports Sciences·N HolmqvistT W Schwartz
Apr 1, 1986·Acta Physiologica Scandinavica·T Bradley, P Hjemdahl
Oct 1, 1985·Journal of Applied Physiology·M KjaerH Galbo
Sep 1, 1985·The Journal of Physiology·P Andersen, B Saltin
Nov 1, 1985·Journal of Applied Physiology·P AndersenB Saltin
May 1, 1967·The American Journal of Physiology·B G Zimmerman, L Whitmore
Apr 1, 1971·Physiological Reviews·P I Korner
Jul 14, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Barker, M Saito
Jan 1, 1983·Annual Review of Physiology·N J Christensen, H Galbo
Mar 1, 1983·The Journal of Clinical Investigation·J HilstedS Madsbad
Apr 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K KlausenJ Trap-Jensen
Jan 1, 1981·Acta Physiologica Scandinavica·B G WallinL E Lindblad
Jul 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·B HesseF B Petersen
Feb 1, 1980·Acta Psychiatrica Scandinavica·N J ChristensenO J Rafaelsen
Aug 1, 1963·The American Journal of Physiology·S ROSELLJ AXELROD
Jan 1, 1965·Journal of Applied Physiology·J T SHEPHERD

❮ Previous
Next ❯


Jun 1, 1994·Muscle & Nerve·A J McComasR W Einhorn
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·E JebensO M Sejersted
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·S BrooksC Williams
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·E Marcos, J Ribas
Apr 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L P Krock, G H Hartung
Dec 3, 2003·Journal of Physiology and Biochemistry·J S BakerB Davies
Jun 9, 2009·European Journal of Applied Physiology·Gerd M FlodgrenM Fahlström
Jan 7, 2010·European Journal of Applied Physiology·Jasper TruijenJohannes J van Lieshout
Feb 4, 2012·European Journal of Applied Physiology·Ilkka HeinonenKari K Kalliokoski
Apr 13, 2010·Pflügers Archiv : European journal of physiology·Anh Thuc NgoChristian Torp-Pedersen
Dec 1, 1990·Physiology & Behavior·A J Scheurink, A B Steffens
May 1, 1995·Progress in Cardiovascular Diseases·R L Moore, D H Korzick
Apr 1, 1993·Baillière's Clinical Endocrinology and Metabolism·P Hjemdahl
May 13, 1998·Acta Physiologica Scandinavica·J Bangsbo, Y Hellsten
Apr 12, 2000·Acta Physiologica Scandinavica·J HansenG D Thomas
Feb 1, 1997·Clinical and Experimental Pharmacology & Physiology·L B Rowell
Nov 1, 1990·Acta Physiologica Scandinavica·E JanssonI Jacobs
Nov 1, 1993·Acta Physiologica Scandinavica·L GullestadO M Sejersted
Apr 1, 1994·Acta Physiologica Scandinavica·G MagnussonB Saltin
Jun 26, 2003·The Journal of Physiology·Dennis W KochDavid N Proctor
Mar 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·M R BoulayC Bouchard
Jul 15, 1996·The Journal of Clinical Investigation·J HansenR G Victor
May 13, 2014·BioMed Research International·Antonio C L NobregaAntonio Crisafulli
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Milène CatoireSander Kersten
Oct 1, 2005·Journal of Sports Sciences·Jan Hoff
Jun 19, 2003·The Journal of Physiology·Thomas Holm PedersenOle Baekgaard Nielsen
May 25, 2004·The Journal of Physiology·Jaya B RosenmeierJosé González-Alonso
May 1, 1987·Baillière's Clinical Endocrinology and Metabolism·M KjaerH Galbo
Nov 3, 2015·The Tohoku Journal of Experimental Medicine·Masayuki OmotoNaoto Shiba
May 5, 2004·Experimental Physiology·Mads K DalsgaardNiels H Secher
Nov 17, 2007·Clinical Physiology and Functional Imaging·Marc CharlesFrédéric Costes
Jun 12, 2014·Frontiers in Physiology·Daniel BoultonSimon Green
Aug 28, 2007·Journal of Science and Medicine in Sport·Mark Hargreaves
Aug 2, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L L SteinbergA C Silva
May 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Damian M BaileyRussell S Richardson
Nov 8, 2001·Canadian Journal of Physiology and Pharmacology·J L Lavoie, L Béliveau
Apr 25, 2020·The Journal of Physiology·Janée D TerwoordFrank A Dinenno

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Hyun-Min ChoiJong-Kyung Kim
American Journal of Physiology. Heart and Circulatory Physiology
Eric J AnsorgeDonal S O'Leary
American Journal of Physiology. Heart and Circulatory Physiology
Elisabetta MarongiuAntonio Crisafulli
American Journal of Physiology. Heart and Circulatory Physiology
Don D Sheriff
© 2021 Meta ULC. All rights reserved