Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors

European Journal of Pharmacology
Masahiko HirafujiM Minami

Abstract

The effect of noradrenaline on 5-hydroxytryptamine (5-HT) release from isolated mouse ileal tissues was investigated. Noradrenaline, but not isoprenaline, at 1 microM stimulated 5-HT release, an effect which was inhibited by yohimbine, an alpha(2)-adrenoceptor antagonist, but not by bunazosin, an alpha(1)-adrenoceptor antagonist. alpha(2)-Adrenoceptor agonists, UK 14,304 (5-bromo-6-(2-imidazolin-2-yl-amino)-quinoxaline) and clonidine at a higher concentration (10 microM) also stimulated 5-HT release, while alpha(1)-adrenoceptor agonists, methoxamine and phenylephrine, had no effect. The effect of noradrenaline was completely abolished in ileal tissues isolated from mouse treated with pertussis toxin (100 microg/kg, i.v.) for 2 days. These results suggest that noradrenaline causes 5-HT release from enterochromaffin cells in mouse ileal tissues via alpha(2)-adrenoceptor subtypes coupled to a pertussis toxin-sensitive G protein.

References

Feb 3, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Birgit AdamGerald Holtmann
Aug 7, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masaru MinamiMasahiko Hirafuji
Nov 27, 2008·World Journal of Gastroenterology : WJG·Cristina HotoleanuDan-L Dumitrascu
Sep 9, 2006·The Journal of Physiology·Paul P Bertrand
Mar 5, 2016·Journal of Neurochemistry·Peter ThornDamien J Keating
Feb 9, 2006·The American Journal of Gastroenterology·Christopher E CamilleriRaul Urrutia

Citations

Aug 1, 1976·The Journal of Allergy and Clinical Immunology·H M Guirgis, R G Townley
Jan 1, 1979·International Archives of Allergy and Applied Immunology·P E Alm, G D Bloom
Nov 1, 1976·Acta Physiologica Scandinavica·H AhlmanJ Kewenter
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Jul 1, 1984·The Journal of Experimental Medicine·D Guy-GrandP Vassalli
Jan 1, 1996·Behavioural Brain Research·K RackéH Kilbinger
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