Noradrenaline triggers GABAA inhibition of bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Eric C Dumont, John T Williams

Abstract

The lateral part of the ventral bed nucleus of the stria terminalis (vlBNST) is a critical site for the antiaversive effects of noradrenergic drugs during opioid withdrawal. The objective of the present study is to identify the cellular action(s) of noradrenaline in the vlBNST after withdrawal from a 5d treatment with morphine. The vlBNST is a heterogeneous cell group with multiple efferent projections. Therefore, neurons projecting to the midbrain were identified by retrograde transport of fluorescent microspheres injected in the ventral tegmental area (VTA). Whole-cell voltage clamp recordings of these neurons and of those sharing physiological properties were done in brain slices. Noradrenaline activated alpha1-adrenergic receptors to increase GABA(A)-IPSC frequency. Noradrenaline produced a similar increase in GABA(A)-IPSCs during acute opioid withdrawal, but this increase resulted from activation of beta-adrenergic receptors, adenylyl cyclase, and protein kinase A, as well as alpha1-adrenergic receptors. Given that neurons in the vlBNST send an excitatory projection to the VTA, noradrenaline may reduce excitatory drive to mesolimbic dopamine cells. This mechanism might contribute to the withdrawal-induced inhibition of dop...Continue Reading

References

Sep 16, 1978·Lancet·M S GoldH D Kleber
Jan 25, 1991·European Journal of Pharmacology·E AcquasG Di Chiara
Dec 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G C Harris, G Aston-Jones
Jan 1, 1993·Brain Research. Brain Research Reviews·P W Kalivas
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·A BecharaD van der Kooy
Jul 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S ErbJ Stewart
Dec 4, 2003·The Journal of Comparative Neurology·Hong-Wei Dong, Larry W Swanson

❮ Previous
Next ❯

Citations

Aug 7, 2013·Neuropharmacology·John R MantschJordan M Blacktop
Mar 22, 2013·Nature·Joshua H JenningsGarret D Stuber
Nov 8, 2011·Nature Neuroscience·Nagore PuenteOlivier J Manzoni
Mar 8, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zoé A McElligottR Mark Wightman
Jul 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco CecchiHuda Akil
Feb 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cynthia Neill EppersonChristian Grillon
Jul 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas L KashDanny G Winder
Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zoé A McElligott, Danny G Winder
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zoé A McElligottDanny G Winder
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jane Stewart
Oct 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Linda Rinaman
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuval SilbermanDanny G Winder
Jul 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julian deBackerÉric C Dumont
Apr 19, 2011·Physiology & Behavior·Linda RinamanThomas J Koehnle
Mar 16, 2011·Physiology & Behavior·Michael S Bienkowski, Linda Rinaman
Aug 18, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Walter FrancesconiPietro Paolo Sanna
Jul 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marion JalabertFrançois Georges
Jun 16, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zoé Anastasia McElligott, Danny G Winder
Apr 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shimon Amir, Jane Stewart
Jul 3, 2007·Frontiers in Neuroendocrinology·Joseph S Lonstein
Dec 2, 2015·Biological Psychiatry·Michael Q SteinmanBrian C Trainor
May 28, 2011·The Journal of Comparative Neurology·Daniel S ZahmRuediger W Veh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.