Noradrenergic blood pressure dysregulation and cytosolic calcium in primary hyperparathyroidism

Kidney & Blood Pressure Research
H SchifflS M Lang

Abstract

The purpose of this study was to characterize the changes in noradrenergic blood pressure regulation and the causes of this dysregulation in patients with histologically proven primary hyperparathyroidism before and after parathyroidectomy. In untreated hypertensive patients with primary hyperparathyroidism slightly higher plasma levels of norepinephrine, enhanced cardiovascular reactivity to norepinephrine (p<0.05) and increased cytosolic free calcium concentration in platelets (p<0.05) were found. Parathyroidectomy resulted in the correction of noradrenergic blood pressure dysregulation and in the reduction of cytosolic free calcium and led to normotension. In vitro incubation of platelets from normal subjects with heterologous plasma ultrafiltrates from either hypertensive patients with primary hyperparathyroidism or normotensive uremic patients with secondary hyperparathyroidism led to raised platelet calcium in primary hyperparathyroidism but not in secondary hyperparathyroidism, although in both conditions intact parathormone levels were elevated equally. Furthermore, when platelets of normotensive subjects were preincubated with commercially available parathormone, no effect on resting platelet cytosolic calcium was obse...Continue Reading

Citations

Mar 23, 2011·International Journal of Endocrinology·Helmut Schiffl, Susanne M Lang
Jul 22, 2005·Journal of Human Hypertension·C LetiziaG F Mazzuoli
May 21, 2014·The Journal of Clinical Endocrinology and Metabolism·Kimon StamatelopoulosMaria Alevizaki
Oct 21, 2020·Current Hypertension Reports·Taniya de SilvaDaniel S Hsia

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