Noradrenergic control of central oxytocin release during lactation in rats

The American Journal of Physiology
S L Bealer, W R Crowley

Abstract

Noradrenergic systems regulate the systemic release of oxytocin (OT) in lactating rats. However, a role for norepinephrine (NE) in release of OT within the magnocellular nuclei during suckling has not been established. These studies were designed to determine 1) if suckling induces NE release in the supraoptic (SON) and paraventricular (PVN) nuclei of conscious rats and 2) the role of NE in the central, intranuclear release of OT within these nuclei. Female Holtzman rats were implanted with microdialysis probes adjacent to the PVN or SON on lactation days 8-12. The following day, the pups were isolated from the dams for 4 h. Microdialysis probes were perfused with artificial cerebrospinal fluid (ACSF) or with ACSF containing an alpha- or a beta-adrenergic receptor antagonist. Dialysate was collected before, during, and after suckling and analyzed for NE or OT. In an additional experiment, an alpha- or beta-adrenergic agonist was administered via the microdialysis probes into the PVN in nonsuckled, lactating rats. Extracellular NE increased in the PVN during suckling but was not detectable in the SON. OT concentrations in dialysates from the PVN and SON significantly increased during suckling. Blockade of either alpha-(in both P...Continue Reading

References

Dec 1, 1979·The Journal of Endocrinology·G ClarkeL P Merrick
Feb 17, 1978·Brain Research·E TribolletD W Lincoln
Jul 1, 1982·Journal of Reproduction and Fertility·D W Lincoln, A C Paisley

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Citations

Feb 14, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cherif Boudaba, Jeffrey G Tasker
Sep 25, 2008·American Journal of Physiology. Endocrinology and Metabolism·R TeruyamaW E Armstrong
May 15, 2020·Journal of Neuroendocrinology·Colin H BrownJavier E Stern
May 20, 2004·American Journal of Physiology. Endocrinology and Metabolism·David L LipschitzSteven L Bealer
Jun 18, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven L BealerWilliam R Crowley

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