Noradrenergic DSP-4 lesions aggravate impairment of working memory produced by hippocampal muscarinic blockade in rats

Pharmacology, Biochemistry, and Behavior
M OhnoS Watanabe

Abstract

To clarify the interactions between hippocampal cholinergic and adrenergic systems in working memory function of rats, the effects of hippocampal muscarinic receptor blockade combined with noradrenaline depletion on this behavior were examined with a three-panel runway task. Intrahippocampal administration of the muscarinic receptor antagonist scopolamine at a dose of 3.2 micrograms/side significantly increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in the working memory task, whereas the 0.32 microgram/side dose of scopolamine did not affect working memory errors. Administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) at 50 mg/kg IP caused a marked reduction in hippocampal noradrenaline concentration, but it had no effect on working memory errors. Intrahippocampal administration of 0.32 microgram/side scopolamine, the behaviorally ineffective dose in intact rats, significantly increased the number of working memory errors in the noradrenaline-depleted animals. These results suggest that hippocampal muscarinic/noradrenergic interactions are involved in neural processes mediating working memory function of rats.

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Citations

May 16, 2012·Attention Deficit and Hyperactivity Disorders·Joachim HauserKlaus W Lange
Oct 3, 2003·Neurobiology of Learning and Memory·María Isabel MirandaFederico Bermúdez-Rattoni
Apr 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Beverly M FrancisHoward T J Mount
Jan 30, 2004·Learning & Memory·Marise B Parent, Mark G Baxter
May 5, 2005·The European Journal of Neuroscience·Christina B Castelino, Gregory F Ball
Jan 23, 2018·The Journal of Comparative Neurology·Roberta PintusGiampiero Leanza
Sep 28, 2018·Frontiers in Neuroscience·Laura M ButkovichMalú G Tansey

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