Noradrenergic function and clinical outcome in antidepressant pharmacotherapy

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
H L MillerR N Golden

Abstract

Controversy remains regarding the role of noradrenergic systems in determining clinical response to antidepressant pharmacotherapy. Pineal gland production of melatonin can serve as a physiologic index of noradrenergic function. The aim of this study was to examine the effects of antidepressant treatment on 24-hour urinary excretion of the principle metabolite of melatonin, 6-sulfatoxymelatonin in treatment responders and nonresponders. Twenty-four outpatients meeting DSM-III-R criteria for Major Depression received treatment with either fluvoxamine or imipramine for 6 weeks while participating in a placebo-controlled double-blind clinical trial. Twenty-four hour excretion of 6-sulfatoxymelatonin was measured at baseline and at the conclusion of the treatment trial. Changes in urinary excretion of 6-sulfatoxymelatonin distinguished antidepressant responders from nonresponders, with a significant increase observed in the former group and a significant decrease in the latter. The degree of clinical response was correlated with the change in 6-sulfatoxymelatonin excretion. These results suggest that enhanced noradrenergic function may play an important role in determining clinical response to antidepressant pharmacotherapy.

Citations

Aug 13, 2011·Purinergic Signalling·Bernardo Carraro DetanicoIraci Lucena da Silva Torres
Apr 17, 2002·Maturitas·Uwe D Rohr, Jens Herold
Mar 6, 2003·CNS Drugs·Dalu Mancama, Robert W Kerwin
Dec 11, 2008·Phytotherapy Research : PTR·Angelo L PiatoElaine Elisabetsky
Jun 18, 2011·Human Psychopharmacology·Maria Paz Loayza HidalgoRegina P Markus
Jun 20, 2008·Journal of Psychopharmacology·Livia A CarvalhoR P Markus
Aug 16, 2003·Endocrine Reviews·Ze'ev HochbergGeorge P Chrousos
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Ichiro M OmoriToshi A Furukawa
Apr 9, 2016·Journal of the American Society of Nephrology : JASN·Adam HosszuAndrea Fekete

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