Noradrenergic innervation of the cerebellar cortex in normal and in Purkinje cell degeneration mutant mice: evidence for long term survival following loss of the two major cerebellar cortical neuronal populations

Neuroscience
D L FeltenB Ghetti

Abstract

Purkinje cell degeneration mutant mice were examined during the course of Purkinje cell death (26 and 35 days old) and at 3, 5, 9 and 12 months of age. Glyoxylic acid fluorescence histochemistry for catecholamines was used to investigate possible alterations or reorganization of the noradrenergic fibers from the coeruleo-cerebellar system in response to the degeneration of two major cell types in the cerebellar cortex, of which one, the Purkinje cell, is reported to be the major target neuron. In control mice, noradrenergic fibers traveled in linear and tortuous profiles through the granule cell layer, formed pericellular arrays alongside Purkinje cell somata, and branched profusely into both radially oriented and longitudinally oriented chains. The density of noradrenergic varicosities diminished in the molecular layer, there was with age. In the mutants, concomitant with the progressive shrinkage of the molecular layer, there was a progressive increase in the density of noradrenergic varicosities. This was most conspicuous at 9 and 12 months of age, at which time the molecular layer has been depleted not only of Purkinje cell dendrites, but also of parallel fibers. Noradrenergic fibers in these zones formed dense parallel bun...Continue Reading

References

Jan 1, 1977·Progress in Neurobiology·D G Amaral, H M Sinnamon
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R J MullenR L Sidman
Oct 15, 1971·Nature·G R SigginsF E Bloom
Nov 1, 1968·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A Björklung, B Falck
Aug 19, 1969·Experimental Brain Research·T Hökfelt, K Fuxe
Oct 15, 1967·Experientia·N E AndénU Ungerstedt
Jul 1, 1980·Journal of Neurochemistry·R N PittmanP B Molinoff
Jan 1, 1982·Journal of Neuroscience Research·J P SchwartzM J Schmidt
Aug 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D L FeltenJ R Sladek
Aug 25, 1980·Brain Research·D A PasquierD M Jacobowitz
Nov 4, 1982·Brain Research·M TouretM Jouvet
Dec 1, 1981·Brain Research Bulletin·B GhettiM J Schmidt

❮ Previous
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Citations

Mar 17, 1997·The Journal of Comparative Neurology·T E NelsonG A Bishop
Aug 1, 1990·Molecular and Chemical Neuropathology·A M DopicoL M Zieher
Feb 27, 1989·Brain Research·R E PowersD L Price
Mar 1, 1987·Brain, Behavior, and Immunity·S L CarlsonS Y Felten
May 4, 2005·Molecular and Cellular Neurosciences·Katrin FärberHelmut Kettenmann
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I PodkletnovaH Alho
Mar 1, 1990·Journal of Microscopy·D L FeltenS J Wiegand
Jul 26, 2012·PloS One·Jennifer BrielmaierJacqueline N Crawley
Oct 16, 2007·Brain Research·Judith A PotashkinGloria E Meredith
May 1, 1990·The Journal of Speech and Hearing Disorders·J H WaltonB E Wilson
Jan 24, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Sarah A LountLinda Hand
Aug 24, 2021·Frontiers in Systems Neuroscience·Paolo FlaceGiuseppe Anastasi

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