Noradrenergic innervation of the developing and mature septal area of the rat

The Journal of Comparative Neurology
John AntonopoulosAthanasios Dinopoulos

Abstract

The noradrenergic innervation of the developing and mature septal area of the rat was examined with light and electron microscopic immunocytochemistry using an antibody against dopamine-beta-hydroxylase. At birth, a small number of relatively thick noradrenergic fibers were found to innervate the lateral septum (mainly its intermediate part) and the nuclei of the vertical and horizontal limbs of the diagonal band of Broca. By postnatal day 7, a substantial increase in their density was observed. At this age some labeled fibers left the medial forebrain bundle and invaded the nucleus of the horizontal limb of the diagonal band. These fibers then ran in a ventrodorsal direction and innervated the nucleus of the vertical limb before entering the medial septum. Immunoreactive fibers were finer and more varicose than at birth. In the subsequent 2 weeks, the density of labeled fibers in the septal area was further increased. By postnatal day 21, the distribution pattern and density of the noradrenergic innervation appeared similar to the adult. In the adult, noradrenergic fibers exhibited more varicosities than in younger rats. Electron microscopic analysis revealed a low proportion (peaked at P7) of noradrenergic varicosities engage...Continue Reading

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Citations

Apr 10, 2012·Cellular and Molecular Neurobiology·América A ScopinhoFernando M A Corrêa
May 12, 2012·Brain Research·Rehana K Leak, Robert Y Moore
Oct 8, 2011·Neurotoxicology and Teratology·V B ThompsonJ W Lipton
Dec 26, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Corina O BondiDavid A Morilak
Jul 22, 2008·British Journal of Pharmacology·A A ScopinhoF M A Corrêa
Dec 20, 2011·Experimental Physiology·América A ScopinhoCarlos C Crestani
Jun 30, 2010·Journal of Neurochemistry·Ramón Sotomayor-ZárateKatia Gysling
Nov 29, 2005·Respiratory Physiology & Neurobiology·Sebastien ZanellaGérard Hilaire
Apr 19, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ming-Yuan MinHsiu-Wen Yang

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