Noradrenergic modulation of arousal

Brain Research Reviews
Craig W Berridge

Abstract

Through a highly divergent efferent projection system, the locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system. State-dependent neuronal discharge activity of locus coeruleus neurons has long-suggested a role of this system in the induction of an alert waking state. More recent work supports this hypothesis, demonstrating robust wake-promoting actions of the locus coeruleus-noradrenergic system. Norepinephrine enhances arousal, in part, via actions of beta- and alpha1-receptors located within multiple subcortical structures, including the general regions of the medial septal area and the medial preoptic areas. Recent anatomical studies suggest that arousal-enhancing actions of norepinephrine are not limited to the locus coeruleus system and likely include the A1 and A2 noradrenergic cell groups. Thus, noradrenergic modulation of arousal state involves multiple noradrenergic systems acting within multiple subcortical regions. Pharmacological studies indicate that the combined actions of these systems are necessary for the sustained maintenance of arousal levels associated with spontaneous waking. Enhanced arousal state is a prominent aspect of both stress and psychostimulant drug ac...Continue Reading

References

Oct 1, 1990·Neuropharmacology·M Trampus, E Ongini
Jul 1, 1989·Brain Research. Molecular Brain Research·R M GubitsH Yu
Jan 1, 1973·The Journal of Pharmacy and Pharmacology·P Lidbrink, K Fuxe
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D S Segal, A J Mandell
Oct 1, 1970·The Journal of Physiology·L M MukhametovV Tradardi
Sep 1, 1970·Physiology & Behavior·C Timo-IariaT Leme da Rocha
Oct 1, 1983·Brain Research·G BuzsákiC H Vanderwolf
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S L FooteF E Bloom
Jan 1, 1997·Annual Review of Neuroscience·D A McCormick, T Bal
May 1, 1997·Pharmacology, Biochemistry, and Behavior·S SoodV M Kumar
Jan 1, 1997·Journal of Psychopharmacology·A F Arnsten
Jul 1, 1997·Trends in Pharmacological Sciences·E Nisoli, M O Carruba
Jul 1, 1997·The Journal of Neuropsychiatry and Clinical Neurosciences·M Davis
May 29, 1998·Brain Research. Molecular Brain Research·C Cirelli, G Tononi
Jul 24, 1998·Behavioral Neuroscience·A J Silvestri, B S Kapp
Nov 24, 1998·Naunyn-Schmiedeberg's Archives of Pharmacology·H C DringenbergJ P Huston
Jan 15, 2000·Science·J L McGaugh

❮ Previous
Next ❯

Citations

May 18, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Verónica G Rodriguez MoncalvoKarin S Pfennig
Aug 7, 2013·Neuropharmacology·John R MantschJordan M Blacktop
Oct 23, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annette Beatrix BrühlUwe Herwig
Aug 6, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen M AlseneVaishali P Bakshi
Jan 21, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen M AlseneVaishali P Bakshi
Oct 4, 2011·British Journal of Anaesthesia·T KushikataK Hirota
Aug 14, 2010·Social Cognitive and Affective Neuroscience·Leonhard SchilbachKai Vogeley
Oct 18, 2011·Current Opinion in Neurology·Andrew M Goldfine, Nicholas D Schiff
Jun 17, 2010·Genes & Development·Amanda Crocker, Amita Sehgal
Apr 23, 2010·Journal of Neurophysiology·John T Serences, Sameer Saproo
Oct 27, 2011·PloS One·Lino BecerraDavid Borsook
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander J ShackmanRichard J Davidson
Jan 21, 2014·Progress in Neurobiology·Ivo F ScheiberRalf Dringen
Jan 15, 2014·Journal of Chemical Neuroanatomy·Geraldine K E GoebrechtJ Matthew Kittelberger
May 21, 2016·Sleep Medicine·Mitchell G Miglis
Sep 10, 2015·Psychophysiology·Stephen B R E BrownSander Nieuwenhuis
Dec 29, 2012·Brain Research·Jesse M S Ellis, Lauren V Riters
Oct 27, 2012·Experimental Parasitology·Justyna GatkowskaHenryka Dlugonska
Aug 10, 2012·International Journal of Nursing Studies·B WilliamsJ McGhee
Jul 7, 2012·Experimental Neurology·Lawrence P Morin
Dec 26, 2015·Neuroscience·Jean-Marie Petit, Pierre J Magistretti
May 22, 2010·Clinics in Chest Medicine·Brandon S Lu, Phyllis C Zee
Oct 17, 2009·Biochemical Pharmacology·Heather A Mitchell, David Weinshenker
Aug 19, 2009·Journal of Chemical Neuroanatomy·Christina B Castelino, Marc F Schmidt
Dec 9, 2008·Brain Research Reviews·Mark F Mehler, Dominick P Purpura
Dec 21, 2012·The European Journal of Neuroscience·Brooke E Schmeichel, Craig W Berridge
Jun 22, 2010·CNS Neuroscience & Therapeutics·Alessandro MartoranaGiacomo Koch
Nov 26, 2010·The European Journal of Neuroscience·Lichao ChenRobert W McCarley
Dec 5, 2009·Depression and Anxiety·Andrew W GoddardAnantha Shekhar
Sep 15, 2009·Brain Research·Craig W BerridgeNicole M Vittoz
Aug 25, 2015·Nature Neuroscience·Ana Raquel O Martins, Robert C Froemke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Related Papers

Sleep Medicine Reviews
Craig W BerridgeR A España
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Craig W Berridge
© 2021 Meta ULC. All rights reserved