Noradrenergic modulation of cognition: therapeutic implications

Journal of Psychopharmacology
Samuel R Chamberlain, Trevor W Robbins

Abstract

The noradrenaline (norepinephrine) system exerts profound influences on cognition via ascending projections to the forebrain, mostly originating from the locus coeruleus. This paper provides an overview of available infrahuman and healthy human studies, exploring the effects of specific noradrenergic manipulations on dissociable cognitive functions, including attention, working memory, cognitive flexibility, response inhibition and emotional memory. Remarkable parallels across species have been reported which may account for the mechanisms by which noradrenergic medications exert their beneficial effects in disorders such as depression and attention-deficit hyperactivity disorder (ADHD). The literature is discussed in relation to prevailing models of noradrenergic influences over cognition and novel therapeutic directions, including in relation to investigating the effects of noradrenergic manipulations on other disorders characterized by impulsivity, and dementias. Unanswered questions are also highlighted, along with key avenues for future research, both proof-of-concept and clinical.

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Citations

Feb 4, 2014·Psychoneuroendocrinology·Anja KuffelKatja Wingenfeld
Oct 8, 2013·CNS Spectrums·Laure-Sophie Camilla d'AngeloSamuel R Chamberlain
Jan 28, 2014·Psychopharmacology·Jessica J Stanis, Susan L Andersen
Jun 5, 2014·Brain : a Journal of Neurology·Angie A KehagiaTrevor W Robbins
Jan 10, 2016·Neurotoxicology·Caridad López-GraneroFernando Sánchez-Santed
Nov 29, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Arun Parashar, Malairaman Udayabanu
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Nov 27, 2015·Brain Research·Debra A BangasserSabina Khantsis
Mar 13, 2016·Neuroscience and Biobehavioral Reviews·Irina Trofimova, Trevor W Robbins
Apr 6, 2016·NeuroImage·Karl-Jürgen BärGerd Wagner
Jul 4, 2015·Psychopharmacology·Mischa de RoverSander Nieuwenhuis
May 17, 2015·Neuroscience and Biobehavioral Reviews·Chong ChenIchiro Kusumi
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Apr 8, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yuanyuan LiQiyong Gong
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Methods Mentioned

BETA
sedation
imaging techniques

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