Noradrenergic modulation of extinction learning and exposure therapy

Behavioural Brain Research
Devin Mueller, Shawn P Cahill

Abstract

Memory consolidation is enhanced by emotional arousal, an effect mediated by noradrenergic beta-receptor signaling. Norepinephrine strengthens consolidation of both appetitive and aversive learning, and is implicated in extinction of conditioned responses. In this review, we summarize work on the noradrenergic mechanisms of extinction learning and implications for extinction-based exposure therapy. The evidence suggests that norepinephrine release evoked by conditioned stimuli during extinction strengthens extinction memory via beta-receptor signaling. The modulatory effect of norepinephrine during extinction depends on predictable presentation of conditioned stimuli and optimal levels of norepinephrine release. Mechanistically, norepinephrine acts to increase cellular excitability and enhance synaptic plasticity within extinction-related neural circuitry. Currently, drugs that modulate norepinephrine are being used to treat symptoms of anxiety disorders, and are now being tested as pharmacotherapeutic prophalactics in the prevention of chronic posttraumatic stress reactions and as adjuncts to extinction-based exposure therapy. Studies of these new applications of noradrenergic drugs show a converging pattern of results with ba...Continue Reading

References

Jan 1, 1977·Pharmacology, Biochemistry, and Behavior·M T PriceH C Fibiger
Apr 6, 1979·Brain Research·S T Mason, H Fibiger
Dec 1, 1978·Physiology & Behavior·S T Mason, S D Iversen
Jun 1, 1978·Physiology & Behavior·G F KoobS T Mason
Jan 1, 1976·Journal of Neuroscience Research·C Torda
Jan 1, 1975·Journal of Experimental Psychology. Animal Behavior Processes·R A Rescorla, C D Heth
Dec 4, 1975·Nature·S T Mason, S D Iversen
Apr 1, 1976·Journal of Comparative and Physiological Psychology·D C RobertsH C Fibiger
Sep 1, 1987·Journal of Affective Disorders·P E Hayes, S C Schulz
Jan 1, 1967·Medicina Et Pharmacologia Experimentalis. International Journal of Experimental Medicine·A B Merlo, I Izquierdo
Jul 15, 1964·Experientia·A Dahlström, K Fuxe
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·S T Mason
May 1, 1983·Pharmacology, Biochemistry, and Behavior·M Dragunow, R Laverty
Oct 20, 1994·Nature·L CahillJ L McGaugh
Apr 1, 1993·Archives of General Psychiatry·S M SouthwickD S Charney
Aug 1, 1997·Archives of General Psychiatry·S M SouthwickD S Charney
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·G L QuirarteJ L McGaugh
Sep 11, 1999·Trends in Neurosciences·E R de KloetM Joëls
Jun 9, 2000·Annual Review of Neuroscience·W Schultz, A Dickinson
Apr 12, 2001·Journal of Experimental Psychology. Animal Behavior Processes·R A Rescorla
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·B Mayr, M Montminy
Feb 28, 2002·Addiction·Cynthia A Conklin, Stephen T Tiffany
May 17, 2002·Current Opinion in Neurobiology·Yadin Dudai
Aug 17, 2002·Trends in Neurosciences·James L McGaugh
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·Mohammad-Reza ZarrindastMohammad Adl
Oct 31, 2002·The European Journal of Neuroscience·Christa K McIntyreJames L McGaugh

❮ Previous
Next ❯

Citations

Apr 23, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steve R MakkarJacquelyn Cranney
Nov 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patricia H JanakLaura H Corbit
May 6, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M Otis, Devin Mueller
Dec 28, 2012·Behavioural Pharmacology·Mate TothVictoria Risbrough
Nov 28, 2012·Journal of Psychiatry & Neuroscience : JPN·Michelle H LonerganAlain Brunet
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James M OtisDevin Mueller
Jun 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sanjeev K BhardwajLalit K Srivastava
Feb 21, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ning ChaiLin Lu
Aug 15, 2014·American Journal of Psychoanalysis·Arash Javanbakht
Dec 10, 2014·Expert Opinion on Drug Discovery·Ryan WyrofskyElisabeth J Van Bockstaele
Feb 10, 2016·Frontiers in Behavioral Neuroscience·Ursula Stockhorst, Martin I Antov
Dec 29, 2015·Journal of Affective Disorders·Megan MahabirJacques Tremblay
Feb 11, 2012·Biological Psychology·Marieke G N BosMerel Kindt
Jan 25, 2011·Pharmacology, Biochemistry, and Behavior·Gary B Kaplan, Katherine A Moore
Dec 15, 2015·Psychopharmacology·Emanuele Claudio LatagliataStefano Puglisi-Allegra
Nov 27, 2015·Brain Research·Debra A BangasserSabina Khantsis
Aug 27, 2015·Behavioural Brain Research·Rodrigo O SierraFernando P Cardenas
Sep 16, 2015·Translational Psychiatry·M B YoungL L Howell
Dec 23, 2014·Neurobiology of Stress·Candace M Raio, Elizabeth A Phelps
Jan 1, 2014·Brain Research Bulletin·Paul J FitzgeraldStephen Maren
Jun 16, 2015·Frontiers in Behavioral Neuroscience·Marion Agnès Emma AndréDenise Manahan-Vaughan
Feb 15, 2015·Psychoneuroendocrinology·Martin I AntovUrsula Stockhorst
Sep 20, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Takeshi InoueTsukasa Koyama
Jan 31, 2012·Pharmacology, Biochemistry, and Behavior·Laura Font, Christopher L Cunningham
Nov 30, 2011·Journal of Behavior Therapy and Experimental Psychiatry·Najwa C CulverMichelle G Craske
May 26, 2016·Neurobiology of Learning and Memory·Andreas M BurgerJos F Brosschot
Jul 28, 2016·Neuroscience and Biobehavioral Reviews·Daniel V ZujKim L Felmingham
May 4, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M Otis, Devin Mueller
Jan 19, 2019·Psychopharmacology·Emma N Cahill, Amy L Milton
Jan 31, 2019·Annual Review of Clinical Psychology·Lauren A M LeboisKerry J Ressler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Devin MuellerGregory J Quirk
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Gregory J Quirk, Devin Mueller
© 2022 Meta ULC. All rights reserved