Feb 9, 2014

Noradrenergic plasticity of olfactory sensory neuron inputs to the main olfactory bulb

BioRxiv : the Preprint Server for Biology
Dennis Eckmeier, Stephen D Shea

Abstract

Sensory responses are modulated throughout the nervous system by internal factors including attention, experience, and brain state. This is partly due to fluctuations in neuromodulatory input from regions such as the noradrenergic locus coeruleus (LC) in the brainstem. LC activity changes with arousal and modulates sensory processing, cognition and memory. The main olfactory bulb (MOB) is richly targeted by LC fibers and noradrenaline profoundly influences MOB circuitry and odor-guided behavior. Noradrenaline-dependent plasticity affects the output of the MOB. However, it is unclear whether noradrenergic plasticity includes modulation in the glomerular layer, the site of input to the MOB. Noradrenergic terminals are found in the glomerular layer, but noradrenaline receptor activation does not seem to acutely modulate olfactory sensory neuron terminals in vitro . We investigated whether noradrenaline induces plasticity at the glomerulus. We used wide-field optical imaging to measure changes in odor responses following electrical stimulation of locus coeruleus in anesthetized mice. Surprisingly, the odor-evoked intrinsic optical signals at the glomerulus were persistently weakened after LC activation. Calcium imaging selectively ...Continue Reading

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Mentioned in this Paper

Fluctuation
Presynaptic Terminals
Calcium [EPC]
Entire Brainstem
Structure of Olfactory Bulb
Calcium
Widening
Suppression, Genetic
Entire Nervous System
Brain

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