Noradrenergic regulation of prolactin secretion at the level of the paraventricular nucleus of the hypothalamus: functional significance of the alpha-1b and beta-adrenergic receptor subtypes

Brain Research
J C Dodge, L L Badura

Abstract

Previous research has demonstrated that in the Siberian hamster, both photoperiod and estrous cyclicity alter the profile of noradrenergic activity with the paraventricular nucleus of the hypothalamus (PVN), and that noradrenergic activity is correlated with changes in circulating levels of prolactin. Work from our laboratory has demonstrated an inhibitory role for norepinephrine (NE) acting at the alpha-2 receptor subtype within the PVN on serum prolactin levels; however, the functional significance of other adrenergic receptor subtypes on this system is unknown. The purpose of this study was to investigate the functional significance of the alpha-1b and beta-adrenergic receptor subtypes at the level of the PVN on circulating levels of prolactin. These experiments were performed in male Siberian hamsters using reverse microdialysis coupled with serial blood sampling. In Experiment 1, infusion of l-phenylephrine hydrochloride (alpha-1b agonist) initiated a dose-dependent increase in circulating prolactin, whereas infusion of chloroethylclonidine (alpha-1b antagonist) induced a significant dose-dependent decline in prolactin. In Experiment 2, intraparaventricular administration of propranolol (beta antagonist) initiated a signif...Continue Reading

References

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Citations

May 15, 2010·The Journal of Pharmacology and Experimental Therapeutics·K S MurnaneL L Howell
Nov 20, 2009·The International Journal of Neuroscience·Joseph Prandota
Sep 15, 2005·Journal of Neuroendocrinology·R E SzawkaJ A Anselmo-Franci
May 6, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Isabella PacchiarottiEduard Vieta

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