Noradrenergic stimulation modulates activation of extinction-related brain regions and enhances contextual extinction learning without affecting renewal

Frontiers in Behavioral Neuroscience
S LissekM Tegenthoff

Abstract

Renewal in extinction learning describes the recovery of an extinguished response if the extinction context differs from the context present during acquisition and recall. Attention may have a role in contextual modulation of behavior and contribute to the renewal effect, while noradrenaline (NA) is involved in attentional processing. In this functional magnetic resonance imaging (fMRI) study we investigated the role of the noradrenergic system for behavioral and brain activation correlates of contextual extinction and renewal, with a particular focus upon hippocampus and ventromedial prefrontal cortex (PFC), which have crucial roles in processing of renewal. Healthy human volunteers received a single dose of the NA reuptake inhibitor atomoxetine prior to extinction learning. During extinction of previously acquired cue-outcome associations, cues were presented in a novel context (ABA) or in the acquisition context (AAA). In recall, all cues were again presented in the acquisition context. Atomoxetine participants (ATO) showed significantly faster extinction compared to placebo (PLAC). However, atomoxetine did not affect renewal. Hippocampal activation was higher in ATO during extinction and recall, as was ventromedial PFC acti...Continue Reading

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Citations

Mar 15, 2016·NeuroImage·Valerie L KinnerOliver T Wolf
Sep 22, 2015·Frontiers in Behavioral Neuroscience·Silke LissekMartin Tegenthoff
May 26, 2016·Neurobiology of Learning and Memory·Andreas M BurgerJos F Brosschot
May 17, 2018·Frontiers in Aging Neuroscience·Andrew C Peterson, Chiang-Shan R Li
Apr 16, 2020·Frontiers in Behavioral Neuroscience·Silke LissekMartin Tegenthoff

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Software Mentioned

SPSS Statistics
Statistical Parametric Mapping ( SPM )
MARINA
Matlab
SPM
MarsBar

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