PMID: 11607040Oct 19, 2001Paper

Norbormide: a calcium entry blocker with selective vasoconstrictor activity in rat peripheral arteries

Cardiovascular Drug Reviews
S BovaG Cargnelli


Norbormide is a unique vasoactive substance endowed with species- and tissue-specific, endothelium independent, vasoconstrictor activity that is restricted to the peripheral arteries of rat. In rat aorta and in all tested arteries of other species norbormide exhibits vasorelaxant property presumably due to the blockade of calcium channels. A calcium entry blocker effect of norbormide has also been described in isolated, perfused guinea pig hearts. In these preparations norbormide produced coronary vasodilator, as well as negative inotropic and dromotropic effects. In single ventricular myocytes of guinea pigs norbormide reduces L-type calcium current. The mechanism underlying the selective vasoconstrictor effect of norbormide is unknown. In rat caudal artery, a vessel contracted by norbormide, the drug activates phospholipase C (PLC) signal cascade which is the biochemical pathway involved in the contractile effect triggered by most receptor-activating vasoactive agents. Therefore, norbormide-induced contraction of rat peripheral vessels is likely to be due to the activation of a PLC-coupled receptor abundantly or selectively expressed in vascular smooth muscle cells. The identification of this putative receptor could facilitat...Continue Reading


Mar 15, 1989·Biochemical and Biophysical Research Communications·E KobayashiT Tamaoki
Mar 1, 1988·British Journal of Pharmacology·S BovaS Luciani
Sep 1, 1971·European Journal of Pharmacology·J Yelnosky, R Lawlor
Mar 1, 1968·The Journal of Hygiene·B D RennisonG L Jones
Jul 1, 1966·Journal of Medicinal Chemistry·G I PoosA P Roszkowski
Nov 1, 1966·The Journal of Organic Chemistry·S Abrahamsson, B Nilsson
Jan 28, 1993·Nature·M J Berridge

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