Abstract
From the roots of Salvia multicaulis, four new aromatic norditerpenoids, multicaulin (1), 12-demethylmulticauline (2), multiorthoquinone (3), and 12-demetylmultiorthoquinone (4), two new abietane diterpenoids, 12-methyl-5-dethydrohorminone (5) and 12-methyl-5-dehydroacetylhorminone (6), as well as a new pimarane diterpenoid, salvipimarone (7), were isolated. Also obtained in this investigation were the known compounds alpha-amyrin, hinokione, horminone, lupeol, manool, 1-oxoferruginol, 18-oxoferruginol, pisiferal, and sempervirol. The structures of compounds 1-7 were established by 1D and 2D NMR techniques and by chemical methods. The antituberculous activity of 1-7 was tested against Mycobacterium tuberculosis strain H37Rv, and all compounds were found to be significantly active, with 2 and 4-6 being the most potent substances. Six of these novel compounds were evaluated against a number of additional bacterial cultures.
Citations
Apr 12, 2008·Journal of Natural Medicines·Rosa Martha Pérez GutiérrezJavier Carmona Jimenez
Apr 6, 2005·Bioorganic & Medicinal Chemistry Letters·Kwang-Hee SonByoung-Mog Kwon
Aug 29, 2003·Phytochemistry·Ayhan Ulubelen
Nov 6, 2001·Journal of Ethnopharmacology·N Lall, J J Meyer
Sep 13, 2012·Chemical Reviews·Yi-Bing WuBin Cong
Jun 7, 2006·Natural Product Research·Zeynep AydogmuşGülaçti Topcu
Nov 7, 2012·Natural Product Research·Burcu ÇulhaoğluGülaçtı Topçu
Mar 5, 2008·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Carole Di GiorgioGuy Balansard
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Nezha RajouaniJean-Claude Daran
Jul 27, 2010·Canadian Journal of Microbiology·Duncan WebsterChristopher A Gray
Mar 4, 2008·Chemical & Pharmaceutical Bulletin·Masahiro TadaRyohei Izumi
Sep 2, 2011·Chemical & Pharmaceutical Bulletin·Li-bin YangHan-dong Sun
Jun 9, 2016·Natural Product Research·Amjad Hussain Atta-Ur-Rahman
Jun 20, 2006·Life Sciences·Sergio R AmbrosioAna M de Oliveira
Jan 23, 2015·International Journal of Medicinal Chemistry·D I UgwuD I Ugwuja
Jul 22, 2014·Natural Product Research·Monica Rosa LoizzoRosa Tundis
Nov 30, 2016·Phytotherapy Research : PTR·Marcus Vinícius Oliveira Barros de AlencarMd Torequl Islam
Jul 1, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Serdar BurmaoğluHasan Seçen
Aug 5, 2000·Phytotherapy Research : PTR·S M NewtonC W Wright
Oct 27, 2017·Natural Product Research·Basma NajarClaudia Giuliani
Sep 25, 2004·Medicinal Research Reviews·Rama P TripathiVinod K Tiwari
Jan 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomas GonecJosef Jampilek
Dec 29, 2006·Chemistry & Biodiversity·Baldomero EsquivelM Teresa Ramírez-Apan
Apr 17, 2010·Chemistry & Biodiversity·Patrícia RijoCristina Moiteiro
May 4, 2004·Oncogene·Mohammad SaleemHasan Mukhtar
Apr 25, 2020·Current Alzheimer Research·Gülaçtı TopçuSeda Damla Hatipoğlu Çakmar
Jun 15, 2018·Molecular Medicine Reports·Qasem AbdallahAmin Abdulmajid
Jun 14, 2020·Current Pharmaceutical Design·Kadidiatou O NdjoubiAhmed A Hussein
Dec 30, 2020·Phytochemistry·Sayyedeh Fatemeh AskariSamira Eghbali
Mar 23, 2021·Journal of Natural Products·Zahra AlizadehNunziatina De Tommasi
Apr 27, 2021·Natural Product Research·Lina M BarhoumiMusa H Abu Zarga
Aug 21, 2014·Journal of Natural Products·Hatice SeçintiHasan Seçen
Apr 28, 2001·Journal of Natural Products·A UlubelenW Voelter
Sep 23, 2000·Journal of Natural Products·L C ChangA D Kinghorn
Jun 28, 2000·Journal of Natural Products·A Ulubelen, G Topcu
Jun 23, 2005·Journal of Agricultural and Food Chemistry·Braulio M FragaAzucena González-Coloma
Jun 28, 2003·Journal of Natural Products·Alejandro F BarreroFouad Mellouki
Oct 15, 2021·Biomedical Chromatography : BMC·Mehmet AkdenizAbdulselam Ertas