Norepinephrine activation of basal cerebral metabolic rate for oxygen (CMRO2) during hypothermia in rats

Anesthesia and Analgesia
E M NemotoH Yonas

Abstract

In an earlier study on the effect of mild hypothermia (34 degrees C) on the cerebral metabolic rate for oxygen (CMRO2) in rats, we used norepinephrine (NE) to support arterial blood pressure while inducing isoelectricity on the electroencephalogram (EEG) with thiopental (TP). Even with administration of sufficient TP to reduce a fully active EEG to an isoelectric EEG, CMRO2 was often unchanged. Based on this observation, we hypothesized that NE had activated CMRO2 despite thiopental coma. Therefore, we studied the effect of NE compared with donor blood (DB) infusion to maintain arterial blood pressure during TP-induced isoelectric EEG on whole-brain CBF (H2 clearance) and CMRO2 during normothermia (38 degrees C) and mild hypothermia (34 degrees C) in rats during 70% N2O/30% O2 analgesia. Cerebral blood flow (CBF) and CMRO2 were measured in four groups of rats at 38 degrees C followed by measurements at either 38 degrees C (two groups) or 34 degrees C (two groups) and during TP-induced EEG isoelectricity. Within each of the two groups at 38 degrees C and 34 degrees C, arterial pressure was sustained by either DB (n = 10) or NE (n = 9) infusion. At 38 degrees C, CMRO2 in the DB and NE groups was 7.92 +/- 1.05 and 6.4 +/- 0.80 mL ...Continue Reading

References

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Citations

Jun 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W ReekerE Kochs
Oct 21, 2006·Neurosurgery·Rocco A ArmondaRandy S Bell
Apr 19, 2003·Critical Care Medicine·Kimberly D StatlerPatrick M Kochanek
Sep 24, 2020·Pharmacology Research & Perspectives·Logan FroeseFrederick A Zeiler
May 20, 2014·The Journal of Physiology·Steven J TrangmarJosé González-Alonso

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