PMID: 11912452Mar 26, 2002Paper

Norepinephrine content and adrenoceptor function in the bladder of cats with feline interstitial cystitis

The Journal of Urology
C A Tony BuffingtonGeorge T Somogyi

Abstract

Interstitial cystitis is a chronic syndrome affecting humans and domestic animals, including cats (feline interstitial cystitis). The aggravation of interstitial cystitis symptoms by stress suggests involvement of the sympathetic nervous system. Studies have identified increased sympathetic nervous system activity in patients with interstitial cystitis but to our knowledge effects on bladder function have not been reported. To address this question we measured bladder norepinephrine (NE) content, the electrical field stimulation flux of NE and acetylcholine (ACh), and the effects of feline interstitial cystitis on adrenoceptor (AR) mediated bladder strip contractility. Bladders were obtained from healthy cats and cats with feline interstitial cystitis. In experiment 1 bladder tissue NE content was determined and the simultaneous release of 3H-NE and 14C-ACh in perfusion bath effluent after electrical field stimulation was measured. NE and ACh release was calculated from the area under the efflux curve. In experiment 2 electrical field stimulation induced contractility of bladder body strips was measured in the presence of 100 nM. to 25 microM. NE only or combined with atipamezole (an alpha2-AR antagonist), propranolol (a beta-A...Continue Reading

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Citations

May 5, 2005·Experimental Neurology·Adrian SculptoreanuLori A Birder
Jan 11, 2007·Nature Clinical Practice. Urology·Lori A Birder, William C de Groat
May 14, 2011·Journal of Veterinary Internal Medicine·C A T Buffington
Feb 3, 2007·American Journal of Veterinary Research·Jodi L WestroppC A Tony Buffington
Nov 8, 2002·Journal of the American Veterinary Medical Association·C A Tony Buffington
Dec 17, 2005·The Journal of Small Animal Practice·B GerberC E Reusch
May 6, 2014·Journal of Feline Medicine and Surgery·C A Tony BuffingtonDennis J Chew
Sep 17, 2004·The Journal of Urology·C A Tony Buffington

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