Norepinephrine-induced contraction of isolated rabbit bronchial artery: role of alpha 1- and alpha 2-adrenoceptor activation

Journal of Applied Physiology
A O ZschauerA Wanner

Abstract

The contractile effect of norepinephrine (NE) on isolated rabbit bronchial artery rings (150-300 microns in diameter) and the role of alpha 1- and alpha 2-adrenoceptors (AR) on smooth muscle and endothelium were studied. In intact arteries, NE increased tension in a dose-dependent manner, and the sensitivity for NE was further increased in the absence of endothelium. In intact but not in endothelium-denuded arteries, the response to NE was increased in the presence of both indomethacin (Indo; cyclooxygenase inhibitor) and NG-nitro-L-arginine methyl ester [L-NAME; nitric oxide (NO) synthase inhibitor], indicating that two endothelium-derived factors, NO and a prostanoid, modulate the NE-induced contraction. The alpha 1-AR antagonist prazosin shifted the NE dose-response curve to the right, and phenylephrine (alpha 1-AR agonist) induced a dose-dependent contraction that was potentiated by L-NAME or removal of the endothelium. The sensitivity to NE was increased slightly by the alpha 2-AR antagonists yohimbine and idazoxan, and this effect was abolished by Indo or removal of the endothelium. Similarly, contractions induced by UK-14304 (alpha 2-AR agonist) were potentiated by Indo or removal of the endothelium. These results sugges...Continue Reading

References

Nov 1, 1992·The American Review of Respiratory Disease·S T O'Rourke, P M Vanhoutte
Jul 1, 1990·The American Journal of Physiology·M T NelsonN B Standen
Sep 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A P Somlyo, B Himpens
Sep 18, 1989·The American Journal of Medicine·P M Vanhoutte, V M Miller
Oct 1, 1989·Medicinal Research Reviews·J C McGrathV G Wilson
Aug 1, 1988·Journal of Applied Physiology·J A BarkerA Wanner
Dec 1, 1982·Journal of Medicinal Chemistry·P B Timmermans, P A van Zwieten
Mar 1, 1982·Journal of the Autonomic Nervous System·J M Doidge, D G Satchell
Jul 12, 1995·Annals of the New York Academy of Sciences·D B Bylund
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·D J OnoratoA Wanner

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Citations

Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J L Tuttle, J C Falcone
Oct 12, 1999·The American Journal of Physiology·R K McMillon, M I Townsley
Aug 30, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Eva Nozik-GrayckClaude A Piantadosi
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Q J Li, L J Janssen
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L J JanssenS Netherton
Feb 18, 2011·British Journal of Pharmacology·L PernomianAm de Oliveira

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