PMID: 29485127Feb 28, 2018Paper

Norepinephrine Inhibits Th17 Cells via β2-Adrenergic Receptor (β2-AR) Signaling in a Mouse Model of Rheumatoid Arthritis

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Yan LiuYu-Ping Peng

Abstract

BACKGROUND Norepinephrine (NE), a neurotransmitter released from the sympathetic nerves, has been shown to be involved in rheumatoid arthritis (RA). However, its role in the sympathetic nervous system in RA is divergent. Herein, we demonstrate that the sympathetic neurotransmitter NE exerts an anti-inflammatory effect in collagen-induced arthritis (CIA), a mouse model of RA, by inhibiting Th17 cell differentiation and function via β2-adrenergic receptor (β2-AR) signaling. MATERIAL AND METHODS CIA was prepared by intradermal injection of collagen type II in the tail base of DBA1/J mice. On the 41st day post-immunization, the mice were used as CIA models. CD4+ T cells from the spleen were purified using magnetic cell sorting and activated with anti-CD3 anti-CD28 antibodies. Th17 cells were polarized from the CD4+ T cells using various antibodies and cytokines. RESULTS Co-expression of CD4 and β2-AR was observed in spleens of both intact and CIA mice. The β2-AR expression in the ankle and spleen was downregulated in CIA mice. CIA induced increases in production of interleukin (IL)-17 and IL-22, CD25-IL-17+ cell percentage, and ROR-γt expression in CD4+ T cells. Importantly, NE reduced the CIA-induced CD4+ T cell shift towards Th17...Continue Reading

Citations

Sep 28, 2018·Frontiers in Neuroscience·Laura M ButkovichMalú G Tansey
Mar 9, 2020·Journal of Neuroinflammation·Yajing WeiShuzhong Yao
Jan 9, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Luca Magistrelli, Cristoforo Comi
Feb 12, 2021·Cellular Signalling·Rebecca SohnZsuzsa Jenei-Lanzl
Jan 8, 2021·Cell & Bioscience·Xiuyun XuanChangzheng Huang
Aug 25, 2021·BMC Musculoskeletal Disorders·Hyun Sook HwangHyun Ah Kim

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