PMID: 6986826Jan 1, 1980Paper

Norepinephrine innervation of the cochlear nuclei by locus coeruleus neurons in the rat

Anatomy and Embryology
L F Kromer, R Y Moore

Abstract

The cochlear nuclei (CN) contain a moderate concentration of norepinephrine (445 +/- 20 ng/g tissue) with dopamine levels (46 +/- 14 ng/g) that are low and within the precursor range expected for a norepinephrine (NE) terminal system. Lesion and horseradish peroxidase (HRP) experiments indicate that this innervation is bilateral and arises from fusiform and multipolar neurons in the locus coeruleus. Autoradiographic and fluorescence histochemical experiments demonstate that locus coeruleus fibers reach the ipsilateral ventral cochlear nuclei via a rostral pathway that projects from the rostral locus coeruleus laterally through the brain stem to the rostral tip of the ventral nuclei. This pathway is located dorsal to the motor and spinal trigeminal nuclei and ventral to the middle cerebellar peduncle. Descending coeruleo-cochlear fibers travel between the fourth ventricle and the vestibular nuclei to enter the acoustic striae. These fibers innervate both the dorsal and ventral nuclei. Contralateral locus fibers reach the CN by crossing in the pontine central gray at the rostral border of the fourth ventricle and by decussating with the fibers of the mesencephalic trigeminal nucleus ventral to the medial longitudinal fasciculus. ...Continue Reading

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Citations

Jun 29, 2001·Journal of Chemical Neuroanatomy·W H Mulders, D Robertson
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P Levitt, J L Noebels
Jun 1, 1996·The European Journal of Neuroscience·U Ebert
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Aug 9, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Marie-Pierre Fournier-GosselinAndres M Lozano
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Jun 14, 2013·Journal of Psychopharmacology·Elemer Szabadi
Sep 15, 2005·Journal of Neurophysiology·Matthew A Xu-Friedman, Wade G Regehr
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Aug 11, 2021·The Journal of Pain : Official Journal of the American Pain Society·Peter D Drummond, Philip M Finch

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