Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Zhiping LiAnna Mae Diehl

Abstract

It is not known why natural killer T (NKT) cells, which modulate liver injury by regulating local cytokine production, are reduced in leptin-deficient ob/ob mice. NKT cells express adrenoceptors. Thus, we hypothesize that the low norepinephrine (NE) activity of ob/ob mice promotes depletion of liver NKT cells, thereby sensitizing ob/ob livers to lipopolysaccharide (LPS) toxicity. To evaluate this hypothesis, hepatic NKT cells were quantified in wild-type mice before and after treatment with NE inhibitors, and in dopamine beta-hydroxylase knockout mice (which cannot synthesize NE) and ob/ob mice before and after 4 weeks of NE supplementation. Decreasing NE activity consistently reduces liver NKT cells, while increasing NE has the opposite effect. Analysis of hepatic and thymic NKT cells in mice of different ages demonstrate an age-related accumulation of hepatic NKT cells in normal mice, while liver NKT cells become depleted after birth in ob/ob mice, which have increased apoptosis of hepatic NKT cells. NE treatment inhibits apoptosis and restores hepatic NKT cells. In ob/ob mice with reduced hepatic NKT cells, hepatic T and NKT cells produce excessive T helper (Th)-1 proinflammatory cytokines and the liver is sensitized to LPS ...Continue Reading

References

Apr 13, 1995·Nature·S A ThomasR D Palmiter
Apr 1, 1996·International Immunology·Y TanakaT Nishimura
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Feb 12, 1998·The Journal of Clinical Investigation·T G KirchgessnerG S Hotamisligil
Apr 18, 1998·Gastroenterology·C P Day, O F James
Oct 19, 1999·The Journal of Clinical Investigation·J K HowardS R Bloom
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Guebre-XabierA M Diehl
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MinagawaT Abo
Jun 8, 2000·Annals of the New York Academy of Sciences·P ZimmetM de Courten
Dec 6, 2000·The Journal of Experimental Medicine·F DieliA Salerno
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H Zarkesh-EsfahaniR J Ross
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R FaggioniC Grunfeld
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Liliane DubuissonJean Rosenbaum
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiaki ShimizuM Wayne Flye
Mar 29, 2002·The Journal of Laboratory and Clinical Medicine·William G BrodbeckJames M Anderson
Apr 24, 2002·Science·Kamel BenlaghaAlbert Bendelac
May 15, 2002·European Journal of Pharmacology·Carla A Luque, Jose A Rey
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masashi EmotoStefan H E Kaufmann
Nov 7, 2002·Cell·Shu TakedaGerard Karsenty
Nov 26, 2002·Journal of Neuroimmunology·John J HaddadBared Safieh-Garabedian
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Gary FauldsPeter Arner

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Citations

May 27, 2010·Journal of the Association for Research in Otolaryngology : JARO·Stéphane F MaisonM Charles Liberman
May 18, 2010·Obesity Surgery·Samer GawriehMichael Olivier
May 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Gabriel PerlemuterSylvie Naveau
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lan WuLuc Van Kaer
Jul 23, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Aristo VojdaniGottfried Kellermann
Oct 13, 2005·Current Opinion in Gastroenterology·Steve Choi, Anna Mae Diehl
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Stephen H CaldwellZhenqi Liu
Aug 6, 2011·Biological Reviews of the Cambridge Philosophical Society·Matthew J HydePaul R Kemp
May 12, 2012·International Journal of Hepatology·Kazuto Tajiri, Yukihiro Shimizu
Dec 7, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Norberto C Chavez-TapiaMisael Uribe
Jan 18, 2008·World Journal of Gastroenterology : WJG·Michael Kremer, Ian N Hines
Apr 13, 2011·World Journal of Gastroenterology : WJG·Michael AdlerMichael Poles
Sep 12, 2013·World Journal of Gastroenterology : WJG·Antonella ScaleraGiovanni Tarantino
Sep 18, 2014·The Journal of Endocrinology·Mark A ExleyLydia Lynch
Dec 8, 2015·Obesity·Heesun NamRon F Morrison
Oct 13, 2009·Clinics in Liver Disease·Wing-Kin SynAnna Mae Diehl
Oct 28, 2009·Biochimica Et Biophysica Acta·Michael TraunerMartin Wagner
Oct 3, 2009·Biochimica Et Biophysica Acta·Xavier PrieurMercedes Ricote
Jun 5, 2007·Clinics in Liver Disease·John Edmison, Arthur J McCullough
Sep 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Jun 23, 2009·European Journal of Immunology·Wing-Kin SynAnna Mae Diehl
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Neil Kaplowitz
Jan 27, 2006·International Journal of Experimental Pathology·Quentin M Anstee, Robert D Goldin
Aug 21, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mary Jane MassonLance R Pohl
Dec 25, 2010·Annals of the New York Academy of Sciences·Ina BergheimKatja Breitkopf-Heinlein
Nov 15, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brittany V Martin-MurphyCynthia Ju
Jun 14, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Junpei SoedaJude A Oben
Jan 18, 2006·Chinese Journal of Digestive Diseases·Xiong Ma, Zhiping Li
Oct 2, 2012·Biochimica Et Biophysica Acta·Bin Gao, Svetlana Radaeva
Apr 19, 2011·Best Practice & Research. Clinical Gastroenterology·Ursula E Lee, Scott L Friedman
Jul 21, 2011·Mediators of Inflammation·Matthaios SpeletasAnastasios E Germenis
Dec 3, 2016·International Journal of Food Sciences and Nutrition·Junpei SoedaJude A Oben
Jan 8, 2008·The American Journal of Gastroenterology·Christine Carter-KentAriel E Feldstein
Apr 7, 2018·Frontiers of Medicine·Shasha ZhuLi Bai
Mar 23, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Giridhar KanuriIna Bergheim
Apr 6, 2018·Neuroimmunomodulation·Tetsuya HiramotoNobuyuki Sudo
Mar 6, 2019·Kidney Research and Clinical Practice·Hee-Seong JangBabu J Padanilam
Oct 23, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satoko HosoyaSumio Watanabe

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