PMID: 1202365Nov 21, 1975Paper

Norepinephrine release from nerve terminals within the rabbit superior cervical ganglion

Naunyn-Schmiedeberg's Archives of Pharmacology
J P NoonR H Roth

Abstract

Norepinephrine-3H (NE-3H) and its metabolic normetanephrine-3H were released from the superfused rabbit SCG incubated in tyrosine-3H in response to preganglionic stimulation. Neither dopamine-3H nor its metabolite, 3-methoxy-tyrosine could be detected in the superfusate from "control" or "nerve stimulated" tissues. Nerve stimulated NE-3H release a) was calcium dependent, b) had a stimulus threshold similar to that of C fibers, c) was not blocked by either 50 micromolar curare or 100 micromolar atropine, d) was abolished by chronic decentralization and e) was elicited by stimulation of both the cervical sympathetic and internal carotid nerves. These results suggest that there is a here-to-for undescribed, noradrenergic pathway which originates elsewhere in the sympathetic chain but terminates in the superior cervical ganglion.

References

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Citations

Dec 1, 1976·European Journal of Pharmacology·M Weinstock, D Cohen
Jun 5, 1986·European Journal of Pharmacology·D M Araujo, B Collier
Jan 1, 1988·Progress in Neurobiology·W Laskey, C Polosa
Jan 1, 1979·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·L P Jager, J A Schievers
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A L Cahill, R L Perlman
Jul 1, 1978·Journal of Neurochemistry·J G WebbP V Halushka
Jan 22, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T C ChuD E Potter
Aug 1, 1977·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J W Phillis

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