Mar 10, 1999

Norepinephrine stimulates lymphoid cell mobilization from the perfused rat spleen via beta-adrenergic receptors

The American Journal of Physiology
H RogauschH O Besedovsky

Abstract

The possibility that norepinephrine (NE) influences lymphoid cell outflow independently of its vasoconstrictor action was investigated in the perfused rat spleen. Using agents that affect the vasoconstrictor tonus of the spleen, we observed an inverse correlation between flow resistance and splenic cell output. The curve obtained served as a reference for evaluating effects of different treatments on the number of cells that are mobilized at defined levels of flow resistance. Perfusion of the beta-adrenergic blocker propranolol either alone or in combination with NE lowered splenic leukocyte outflow clearly beyond the number of cells expected at the corresponding flow resistance. No comparable effects were observed when the alpha-adrenergic blocker phentolamine was perfused. When the vasoconstrictor effect of NE was counteracted by papaverine, splenic cell outflow was significantly higher than expected for the level of flow resistance attained. Furthermore, when NE was perfused together with endotoxin, which does not inhibit the vasoconstriction induced by catecholamines, splenic cell mobilization was severalfold higher than expected at increased flow resistance. Propranolol abrogated this effect to a large extent. Furthermore,...Continue Reading

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Mentioned in this Paper

Study
Papaverine
Catecholamine [EPC]
Cell Motility
Spleen
Pathologic Vasoconstriction
Perfusion
Lymphoid Cells
Catecholamines Measurement
Drug Retention

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