Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension

Neuroscience
Nancy R KellerD Robertson

Abstract

The study of anxiety and fear involves complex interrelationships between psychiatry and the autonomic nervous system. Altered noradrenergic signaling is linked to certain types of depression and anxiety disorders, and treatment often includes specific transporter blockade. The norepinephrine transporter is crucial in limiting catecholaminergic signaling. Norepinephrine transporter-deficient mice have increased circulating catecholamines and elevated heart rate and blood pressure. We hypothesized, therefore, that reduced norepinephrine clearance would heighten the autonomic cardiovascular response to anxiety and fear. In separate experiments, norepinephrine transporter-deficient (norepinephrine transporter-/-) mice underwent tactile startle and trace fear conditioning to measure hemodynamic responses. A dramatic tachycardia was observed in norepinephrine transporter-/- mice compared with controls following both airpuff or footshock stimuli, and pressure changes were also greater. Interestingly, in contrast to normally elevated home cage levels in norepinephrine transporter-deficient mice, prestimulus heart rate and blood pressure were actually higher in norepinephrine transporter+/+ animals throughout behavioral testing. Upon p...Continue Reading

References

May 1, 1995·The American Journal of Cardiology·I KawachiS T Weiss
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
Oct 7, 1998·Progress in Neurobiology·N Singewald, A Philippu
Mar 8, 2000·Learning & Memory·S G AnagnostarasA J Silva
May 12, 2000·Journal of the American College of Cardiology·W K ShenS C Hammill
Oct 12, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·J Biederman, T J Spencer
Feb 13, 2001·Journal of Affective Disorders·J F Thayer, R D Lane
Aug 4, 2001·Autonomic Neuroscience : Basic & Clinical·G BaselliM Pagani
Jan 5, 2002·Journal of Psychiatric Research·Marianne B Müller, Martin E Keck
Jul 12, 2002·Drugs·John J SramekNeal R Cutler
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Oct 18, 2003·The Psychiatric Clinics of North America·Teresa A Pigott
Feb 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Luis F JoaquimMariana Morris
Dec 25, 2004·Endocrinology·Jill B BeckerElizabeth Young

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Citations

Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zoé A McElligott, Danny G Winder
Jul 6, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Brett A EnglishRandy D Blakely
Apr 26, 2011·Advances in Medical Sciences·A J D NelsonH J Cassaday
Jun 16, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zoé Anastasia McElligott, Danny G Winder
Dec 26, 2006·Molecular and Cellular Neurosciences·Uhna Sung, Randy D Blakely
Oct 22, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Joseph BiedermanStephen V Faraone
Oct 10, 2013·Genes, Brain, and Behavior·H M FentressM K Hahn
Jun 23, 2011·Neurochemistry International·Joanna SolichMarta Dziedzicka-Wasylewska
Oct 14, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Harald M Stauss
Aug 4, 2007·The Journal of Pharmacology and Experimental Therapeutics·John N MasonRandy D Blakely

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