Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[¹⁸F]FMeNER-D₂

The International Journal of Neuropsychopharmacology
Harumasa TakanoTetsuya Suhara

Abstract

Norepinephrine transporter (NET) plays important roles in the treatment of various neuropsychiatric disorders, such as depression and attention deficit hyperactivity disorder (ADHD). Nortriptyline is a NET-selective tricyclic antidepressant (TCAs) that has been widely used for the treatment of depression. Previous positron emission tomography (PET) studies have reported over 80% serotonin transporter occupancy with clinical doses of selective serotonin reuptake inhibitors (SSRIs), but there has been no report of NET occupancy in patients treated with relatively NET-selective antidepressants. In the present study, we used PET and (S,S)-[18¹⁸F]FMeNER-D₂ to investigate NET occupancies in the thalamus in 10 patients with major depressive disorder taking various doses of nortriptyline, who were considered to be responders to the treatment. Reference data for the calculation of occupancy were derived from age-matched healthy controls. The result showed approximately 50-70% NET occupancies in the brain as a result of the administration of 75-200 mg/d of nortriptyline. The estimated effective dose (ED₅₀) and concentration (EC₅₀) required to induce 50% occupancy was 65.9 mg/d and 79.8 ng/ml, respectively. Furthermore, as the minimum the...Continue Reading

References

Aug 1, 1985·Acta Psychiatrica Scandinavica·P J PerryM T Tsuang
Aug 7, 1971·British Medical Journal·M AsbergD Tuck
Dec 1, 1994·Brain Research. Molecular Brain Research·M M ShoresR C Veith
Sep 5, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·N BrunelloG Racagni
Feb 20, 2003·The Journal of Clinical Psychiatry·Andrew A NierenbergMaurizio Fava
Jan 28, 2004·Biological Psychiatry·Saloua BenmansourAlan Frazer
Jan 28, 2004·Biological Psychiatry·S Neil VaishnaviMichael J Owens
Oct 16, 2004·International Clinical Psychopharmacology·Kousuke KanemotoTatsuo Sekine
Nov 20, 2004·Pharmacopsychiatry·P BaumannUNKNOWN Arbeitsge-meinschaft fur neuropsychopharmakologie und pharmakopsychiatrie
Sep 6, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Magnus SchouHåkan Hall
Mar 1, 2006·Psychopharmacology·Akihiro TakanoTetsuya Suhara
May 2, 2007·British Journal of Pharmacology·P K Gillman
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ryosuke ArakawaTetsuya Suhara
Oct 7, 2008·Clinical Neuropharmacology·W Reed ShimbergTheresa A Zesiewicz
Mar 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Rudolf UherPeter McGuffin
Dec 16, 2010·CNS Neuroscience & Therapeutics·Bernardo Dell'OssoA Carlo Altamura
Sep 3, 2011·Journal of Affective Disorders·Baumeister Harald, Parker Gordon
Jan 17, 2012·The International Journal of Neuropsychopharmacology·Johan LundbergLars Farde

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Citations

May 16, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Arnold F Jacobson, Mark I Travin
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Jacqueline A M SmithS T Patil
Oct 11, 2017·The International Journal of Neuropsychopharmacology·Sho MoriguchiTetsuya Suhara
Jan 17, 2019·The International Journal of Neuropsychopharmacology·Ryosuke ArakawaJohan Lundberg
Mar 30, 2017·Journal of Family Medicine and Primary Care·Gautham SrinivasanB Joseph John
Oct 23, 2018·The International Journal of Neuropsychopharmacology·Ryosuke ArakawaChrister Halldin
May 29, 2020·Neuropsychopharmacology Reports·Ryosuke ArakawaChrister Halldin
May 13, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·C B EapC Hiemke

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