Norepinephrine turnover in the heart and spleen of the cardiomyopathic Syrian hamster.

Circulation Research
M J SoleR J Wurtman

Abstract

Although a reduction in myocardial norepinephrine stores in cardiac hypertrophy and congestive failure is well documented, norepinephrine turnover has been inadequately studied in such hearts. We compared norepinephrine turnover in control and cardiomyopathic hamsters by following the decline in specific activity of myocardial norepinephrine after labelling with an intraperitoneal tracer dose of 3H-norepinephrine. Adult myocardial norepinephrine concentrations were not attained until 4 weeks of age in both strains. There was no difference in the rate of constant (K) for myocardial norepinephrine turnover (0.107+/-0.004 hours-1 vs. 0.100+/-0.005 hours-1) in the two strains of hamsters during the neonatal period. In young control hamsters, K fell to 0.064+/-0.004 hours-1, but that for age-matched hamsters with mild cardiac hypertrophy was 0.102+/-0.001 hours-1 (P less than 0.001). There was little change in K as control hamsters aged. With the development of more severe hypertrophy in cardiomyopathic hamsters, cardiac norepinephrine decreased and resting K rapidly increased to approach the value obtained when hamsters were subjected to immobilization stress (0.302+/-0.013 hours-1). The maximum achievable K remained the same for b...Continue Reading

References

May 1, 1973·Cardiovascular Research·V DequattroJ Verska
Aug 28, 1965·Nature·J E FischerI J Kopin
Aug 1, 1971·Japanese Circulation Journal·N Yamazaki, K Ogawa
Jul 1, 1972·Progress in Cardiovascular Diseases·W F Friedman
Aug 1, 1966·Circulation Research·J F SpannE Braunwald
Sep 1, 1964·Journal of Applied Physiology·D E DONALDJ T SHEPHERD

❮ Previous
Next ❯

Citations

Nov 23, 1994·Molecular and Cellular Biochemistry·R SethiN S Dhalla
Mar 1, 1977·Journal of Molecular and Cellular Cardiology·M J SoleE H Sonnenblick
Jul 1, 1979·Journal of the Neurological Sciences·I H FraserC C Liew
Jan 1, 1983·Pharmacology & Therapeutics·W H Newman
Mar 1, 1982·Journal of the Autonomic Nervous System·D D LundR Roskoski
Aug 26, 1998·Progress in Cardiovascular Diseases·J Joseph, E M Gilbert
Nov 1, 1983·Journal of the American College of Cardiology·C KawaiA Matsumori
Dec 1, 1988·Journal of the American College of Cardiology·S M FactorA Malhotra
Nov 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·H TakatsuH Fujiwara
Mar 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·M EstorchG Torres
Jun 14, 1990·The New England Journal of Medicine·C Rose
Nov 1, 1978·The Journal of Clinical Investigation·L D Horwitz, V L Travis
May 1, 1989·The Journal of Clinical Investigation·J GutkowskaP Sirois
Sep 2, 2008·Heart Failure Clinics·Ron Blankstein, George L Bakris
May 1, 1985·Progress in Cardiovascular Diseases·S M Factor, E H Sonnenblick
Aug 1, 1987·The American Journal of Cardiology·G L PierpontJ N Cohn
Jul 1, 1983·Muscle & Nerve·G Jasmin, L Proschek
Dec 12, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Kok Wah Hew, Kit A Keller
Jan 1, 1979·Annals of the New York Academy of Sciences·J E StrobeckE H Sonnenblick
May 7, 2002·Canadian Journal of Physiology and Pharmacology·Danica BrousseauLouis Dumont
Sep 7, 2000·Journal of Cardiovascular Pharmacology·P L GiudiceP Carminati
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Marcus Lindenberger, Toste Länne
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·P SiltanenJ Pispa
Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K P PatelP K Carmines
Sep 1, 1990·Basic Research in Cardiology·M BhaskarY S Reddy
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A IgawaH Inoue
Dec 1, 1984·The American Journal of Physiology·J TriandafillouJ Himms-Hagen
Jun 3, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Arnold F Jacobson, Jagat Narula

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.